【摘要】 目的探析血浆纤维蛋白原(FIB)与D-二聚体(D-D)预防老年下肢骨折患者下肢深静脉血栓形成(DVT)的临床价值。方法 126例老年下肢骨折患者为观察组,另选取同期126例健康老年人作为对照组。分别检测两组研究对象的FIB与D-D,并依据检测结果将观察组患者分为DVT组(24例)及非DVT组(102例)。比较观察组术前与对照组的FIB、D-D水平, DVT组与非DVT组术前、术后3 d的FIB、D-D水平, DVT组与非DVT组的Caprini评分, DVT组Caprini评分、FIB、D-D的相关性。结果观察组术前的FIB、D-D水平分别为(4.64±1.62)g/L、(388.00±95.99)μg/L,均明显高于对照组的(2.79±0.72)g/L、(111.57±50.20)μg/L,差异均具有统计学意义(P<0.05)。DVT组与非DVT组术前的FIB、D-D水平比较,差异均无统计学意义(P>0.05);DVT组术后3 d的FIB、D-D水平明显高于非DVT组,差异均具有统计学意义(P<0.05)。DVT组的Caprini评分(7.34±1.90)分明显高于非DVT组的(3.45±1.22)分,差异具有统计学意义(P<0.05)。Pearson相关分析显示, DVT组FIB与D-D水平呈正相关(r=0.829,P<0.01)。Caprini评分与FIB、D-D水平呈正相关(r=0.660、0.750, P<0.01)。结论 FIB与D-D是老年下肢骨折患者预防DVT的敏感指标,具有重要的临床检测意义。更多还原

【Abstract】 Objective To discuss and analyze the clinical value of fibrinogen(FIB) and D-dimer(DD) in preventing deep vein thrombosis(DVT) in elderly patients with lower extremity fracture. Methods There were 126 elderly patients with lower extremity fracture selected as the observation group, and another 126 healthy elderly persons at the same time as the control group. FIB and D-D of the two groups were detected respectively, and the patients in the observation group were divided into DVT group(24 cases) and non-DVT group(102 cases) according to the detection results. Comparison was made on levels of FIB and D-D between the observation group before surgery and the control group, and between DVT group and non-DVT group before surgery and 3 d after surgery. Correlation of Caprini score between DVT group and non-DVT group, and Caprini score, FIB, D-D in DVT group was observed. Results Before surgery, the levels of FIB and D-D of the observation group were(4.64±1.62) g/L and(388.00±95.99) μg/L respectively, which were obviously higher than those of the control group(2.79±0.72) g/L and(111.57±50.20) μg/L, and the difference was statistically significant(P<0.05). There was no statistically significant difference in levels of FIB and D-D before surgery between DVT group and nonDVT group(P>0.05). 3 d after surgery, the levels of FIB and D-D of DVT group were obviously higher than those of non-DVT group, and the difference was statistically significant(P<0.05). Caprini score(7.34±1.90) points of DVT group was obviously higher than that of non-DVT group(3.45±1.22) points, and the difference was statistically significant(P<0.05). Pearson correlation analysis showed that there was a positive correlation between FIB and D-D in DVT group(r= 0.829, P< 0.01), and Caprini score was positively correlated with FIB and D-D levels(r=0.660, 0.750, P<0.01). Conclusion FIB and D-D are sensitive indexes for the prevention of DVT in the elderly patients with lower extremity fracture, which have important clinical significance.更多还原