【摘要】 目的明确雾化吸入布地奈德对轻、中度毛细支气管炎的治疗效果。方法采用多中心、随机、对照临床试验方法,于2017年9月至2019年6月对来自国内18个儿科呼吸中心的209例毛细支气管炎婴幼儿患者进行本研究。将209例患儿随机分为3组,分别为对照组、布地奈德治疗1组(0.5 mg/次)、布地奈德治疗2组(1.0 mg/次)。各组患儿月龄、性别、病程、入院时白细胞计数、C反应蛋白(C-reaction protein,CRP)、病情严重程度等基本资料差异均无统计学意义(P>0.05)。分组治疗后,从喘息、咳嗽、哮鸣音、水泡音、三凹征等方面按照严重程度进行评分。结果在治疗开始第1天,每2 h进行1次评分;第2天,每4 h进行1次评分;第3～7天,每6 h进行1次评分,3组患儿在以上各个时间点的病情评分差异均无统计学意义(P>0.05)。结论雾化吸入布地奈德并不能显著降低轻、中度毛细支气管炎患儿的临床症状评分。更多还原

【Abstract】 Objective To make clear the therapeutic effect of budesonide inhalation on mild or moderate bronchiolitis. Methods A multicenter,randomized,controlled clinical trial was conducted. Totally 209 infants with bronchiolitis from 18 pediatric respiratory centers in China were selected and were randomly divided into 3 groups:the control group,the budesonide treatment group 1(0.5 mg/time)and the budesonide treatment group 2(1.0 mg/time).There was no statistical difference in the basic data of children concerning age,gender,course of disease,WBC count on admission,C-reactive protein(CRP)or severity of disease(P>0.05). After treatment,the three groups were given scores regarding the severity of gasping,coughing,wheezing,bubbling rales,and three concave signs. Results On the first day of treatment,scores were given every 2 hours;on the second day,scores were given every 4 hours;on the 3 rd to 7 th day,scores were given every 6 hours. There was no significant difference among the three groups in the scores given at each of the above time points(P>0.05). Conclusion Budesonide inhalation does not effectively reduce the clinical symptom score in children with mild or moderate bronchiolitis.更多还原