【摘要】 目的考察辅酶Q₁₀普利醇环糊精磷脂分散体系的制备、理化性质及其在大鼠体内的生物利用度。方法制备辅酶Q₁₀普利醇环糊精磷脂分散体系;采用差示扫描、红外光谱、粒度分布、透射电镜研究分散体系的理化性质,考察体外溶出和贮存稳定性,以及辅酶Q₁₀普利醇环糊精磷脂分散体系在大鼠体内的生物利用度。结果辅酶Q₁₀普利醇环糊精磷脂分散体系不同于几种原料混合物与包合物,复水后平均粒径为（187.4±3.2）nm,呈不规则圆形,溶出速率明显提高,稳定性考察中各项指标均未发生明显变化。辅酶Q₁₀普利醇环糊精磷脂分散体系、辅酶Q₁₀普利醇环糊精包合物的生物利用度分别是辅酶Q₁₀的2.80倍、1.68倍。结论辅酶Q₁₀普利醇环糊精磷脂分散体系可以有效提高辅酶Q₁₀和普利醇的体外溶出度以及辅酶Q₁₀的口服生物利用度。更多还原

【Abstract】 Objective To prepare coenzyme Q₁₀-policosanol-β-cyclodextrin-lecithin dispersion system and to determine its physicochemical properties and bioavailability in rats.Methods Coenzyme Q₁₀-policosanol-β-cyclodextrin-lecithin dispersion system was prepared and its physicochemical properties were studied by differential scanning calorimetry,fourier transform infrared spectroscopy,particle size distribution and transmission electron microscopy.In vitro dissolution test and storing stability of dispersion system were determinated.The bioavailability of the dispersion system in rats was carried out.Results The dispersion system was different from that of the mixture of several raw materials and inclusion complexes,with an average particle size of （187.4±3.2） nm after rehydration showing irregular round shape.The dissolution rate of the dispersion system was significantly increased.There was no significant change in those indexes for storing stability.The bioavailability of the coenzyme Q₁₀-policosanol-β-cyclodextrin-lecithin dispersion system and the coenzyme Q₁₀-policosanol-β-cyclodextrin inclusion complexes were 2.80 and 1.68 times of coenzyme Q₁₀,respectively.Conclusion Coenzyme Q₁₀-policosanol-β-cyclodextrin-lecithin dispersion system can effectively improve the in vitro dissolution of coenzyme Q₁₀ and policosanol and oral bioavailability of coenzyme Q₁₀.更多还原