【摘要】 目的研究中华卷柏中木脂素类化合物。方法采用硅胶、聚酰胺、LH-20柱色谱和半制备高效液相等现代色谱分离技术对中华卷柏75%乙醇提取液进行分离纯化,根据化合物的理化性质和波谱数据进行结构鉴定。结果从中华卷柏75%乙醇提取液中分离并鉴定了4个木脂素类化合物,分别为(7R,8S)-ceplignan(1)、2,3-trans-3,4-trans-2-methoxy-3-hydroxymethyl-4-[bis-(4-hydroxyphenyl)methyl]tetrahydrofuran(2)、(8S,8’R,7’R)-[tetrahydro-5-(3-hydroxy-4-methoxyphenyl)-4-(hydroxymethyl)-3-furanyl]-3-hydroxy-4-methoxyphenyl-methanone(3)、(+)-isolariciresinol(4)。结论化合物1、3、4是首次从该植物中分离得到,化合物3是首次在卷柏属植物中被发现。更多还原

【Abstract】 Objective To determine the chemical constituents in Selaginella sinensis(Desv.) Spring.Methods Selaginella sinensis was extracted by 75% ethanol,followed by isolation and purification with column chromatography over silica gel,polyamide,Sephadex LH-20,and semi-prepared high performance liquid phase(ODS).The compounds structures were elucidated by physicochemical properties and spectroscopic methods.Results Four lignans were obtained and identified as(7 R,8 S)-ceplignan(1),2,3-trans-3,4-trans-2-methoxy-3-hydroxymethyl-4-[bis-(4-hydroxyphenyl) methyl] tetrahydrofuran(2),(8 S,8’R,7’R)-[tetrahydro-5-(3-hydroxy-4-methoxyphenyl)-4-(hydroxymethyl)-3-furanyl]-3-hydroxy-4-methoxyphenyl-methanone(3),and(+)-isolariciresinol(4).Conclusion For the first time,compound 1,3 and 4 are separated from this plant,while compound 3 from genus Selaginellacea.更多还原