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丁苯酞对缺血性脑卒中静脉溶栓后24 h内序贯治疗的有效性及安全性研究
Efficacy and Safety of Butylphthalide in 24 h Sequential Therapy after Intravenous Thrombolysis for Ischemic Stroke
【摘要】 目的观察和评价丁苯酞注射液在超早期缺血性脑卒中静脉溶栓后24 h内序贯治疗的有效性和安全性.方法选取100例发病时间在4.5 h内的脑卒中患者,根据患者随机及自愿的原则,将其分为溶栓治疗组(常规治疗+rt-PA静脉溶栓)、丁苯酞序贯治疗组(常规治疗+rt-PA静脉溶栓+丁苯酞注射液序贯治疗),每组50例.两组患者常规基础治疗相同,丁苯酞注射液于溶栓后24 h内应用,剂量为100 m L,2次/d静点,时间间隔>6 h,连续治疗14 d,随访观察90 d,比较两组的疗效及安全性.结果溶栓后2周,溶栓治疗组和丁苯酞序贯治疗组患者的NIHSS评分分别为(6.28±2.69)分和(5.16±2.00)分,总有效率分别为80.0%和94.0%,差异具有统计学意义(P<0.05);治疗后随访90 d,溶栓治疗组和丁苯酞序贯治疗组患者的Bl评分分别为(79.20±8.41)分和(88.10±6.37)分,mRS评分分别为(1.94±0.93)分和(1.02±0.68)分,差异具有统计学意义(P<0.05).结论静脉溶栓后24 h内应用丁苯酞注射液可以显著改善患者的预后.
【Abstract】 Objective To observe and evaluate the efficacy and safety of butylphthalide injection in the sequential treatment of ultra-early ischemic stroke within 24 hours after intravenous thrombolysis. Method One hundred stroke patients who met the inclusion and exclusion criteria were selected as the study subjects,the onset time was within 4. 5 hours. According to the principle of random and voluntary patients,they were divided into thrombolytic therapy group,namely routine treatment rt-PA intravenous thrombolytic therapy group,butyphthalide sequential therapy group,namely routine treatment rt-PA intravenous thrombolytic butyphthalide injection sequential therapy group,50 patients in each group. The patients in the two groups were treated with the same routine basic treatment.Butyphthalide injection was used within 24 hours after thrombolysis.The dose was 100 mL per day,2 times static point,over 6 hours interval,14 days continuous treatment,90 days follow-up observation,compared with the efficacy and safety of the two group.Results Two weeks after thrombolysis,the NIHSS scores of the thrombolytic therapy group and the butyphthalide sequential therapy group were( 6.28 ±2.69) and( 5.16±2.00),respectively,and the total effective rates were 80.0% and 94.0%,respectively. After 90 days of followup,patients in the control group had a BI score( 79.20 ±8.41),while those in the treatment group had BI score( 88.10 ±6.37),mRS,respectively( 1.94 ±0.93) and( 1.02 ±0.68),the difference was statistically significant( P<0.05).Conclusion Application of butylphthalide injection within 24 hours after intravenous thrombolysis can significantly improve the prognosis of patients.
【Key words】 intravenous thrombolysis; butylphthalide injection; sequential therapy; acute ischemic stroke;
- 【文献出处】 北华大学学报(自然科学版) ,Journal of Beihua University(Natural Science) , 编辑部邮箱 ,2020年03期
- 【分类号】R743.3
- 【被引频次】4
- 【下载频次】63