【摘要】 农药是关系到国家粮食安全的重要战略物资。随着科学技术的不断发展和农药登记管理的日益严格,传统随机筛选的农药创制研究模式已无法适应现代农业和环境保护的新要求。农药靶标组是指来源于不同种属的野生型作用靶标及其突变型靶标所构成的靶标群。农药靶标组和农药活性分子的相互作用机制研究是农药化学生物学的核心科学问题,是开展农药分子设计的理论基础。本文在比较农药分子设计与医药分子设计异同点的基础上,提出了农药靶标组的概念,指出化学生物学导向的绿色农药分子设计已逐渐发展为绿色农药创制的主流研究模式。更多还原

【Abstract】 Pesticide is one of the important strategic materials associated with food security.With the continuous development of science & technology and the increasingly strict management of pesticide registration,it is impossible for pesticide chemists to take the traditional research mode of random screening to meet the new requirements of modern agriculture and environmental protection.Herein,we put forward the new concept of pesticide targetome by comparing pesticide discovery with drug discovery.Pesticide targetome is a group of target from different species consisted of wild-type molecular target and its mutant.The interaction mechanism between pesticide targetome and small molecules is the key of pesticide chemical biology research and the theoretical basis of molecular design of green pesticide.Chemical biologyoriented green pesticide design is becoming the mainstream research mode of green pesticide discovery.更多还原