【摘要】 构建了Fe₃O₄@SiO₂@C₁₄mimBF₄磁性混合半胶束固相萃取体系,结合超高效液相色谱法,分析检测了环境水体中的痕量磺胺类药物。考察了C₁₄mimBF₄浓度、Fe₃O₄@SiO₂用量、离子强度、超声萃取时间等因素对磺胺药物萃取效果的影响。结果表明,在pH值为10的碱性条件下,10 mL水样中加入5 mg Fe₃O₄@SiO₂和最终质量浓度为300μg/mL的C₁₄mimBF₄可以实现4种磺胺类化合物（磺胺噻唑、磺胺甲二唑、磺胺苯甲酰、磺胺氯吡嗪）的快速吸附。结合超高效液相色谱法,所建立的方法检出限为1.21～2.25μg/L,水样加标回收率为70%～100%,可用于环境水体中磺胺类药物的痕量分析。与传统的固相萃取方法相比,该方法具有绿色环保（有机溶剂用量少,磁性材料用量少并可重复利用）、简便快速（磁性分离操作简便、分离速度快,避免繁琐的过柱程序）、分析物易洗脱等优点。更多还原

【Abstract】 A magnetic mixed hemimicelles solid phase extraction system based on Fe₃O₄@SiO₂@C₁₄mimBF₄ was established for determination of trace sulfonamides in water via ultra performance liquid chromatography（UPLC）. Factors affecting the extraction efficiencies of sulfonamides, including concentration of C₁₄mimBF₄, amount of Fe₃O₄@SiO₂, ionic strength and extraction time, were explored and optimized. The results showed that when pH value was 10, 5 mg of Fe₃O₄@SiO₂ and 300 μg/mL of C₁₄mimBF₄ could rapidly adsorb four kinds of sulfonamides（sulfathiazole, sulfamethizole, sulfabenzamide and sulfaclozine） from 10 mL of water. UPLC analysis showed that detection limits of the established method were in the range of 1.21～2.25 μg/L and recoveries were between 70% and 100%, indicating the method is reliable for trace analysis of sulfonamides in water. Compared with traditional solid phase extraction methods, the reported method here exhibits many advantages, such as environmental friendliness（less consumption of organic solvent and magnetic material and repetitive use of magnetic material）, simple and fast operation（convenient magnetic separation） and easy elution of analyte.更多还原