【摘要】 目的探讨腹腔镜胃癌根治术在早期胃癌的近期临床疗效和免疫水平。方法回顾性分析2016年1月至2018年12月124例早期胃癌的患者资料,将其分为腔镜组与开腹组,每组各62例。采用SPSS21.0统计软件进行分析,围术期各项指标及免疫学指标采用■表示,独立t检验;临床治疗效果采用秩和检验;并发症发生率采用χ~2检验,P<0.05为差异具有统计学意义。结果腔镜组患者的术中出血量少于开腹组,而手术时间、肛门排气时间、下床活动时间、进食时间和术后住院时间均短于开腹组(P<0.05),而总不良反应发生率(9.7%)低于开腹组(25.8%);治疗后两组患者的hs-CRP、IL-6和TNF-α值均有所升高,而腔镜组患者升高值均低于开腹组,差异均有统计学意义(P<0.05)。结论腹腔镜胃癌根治术对早期胃癌患者治疗的手术效果优于开腹胃癌根治术,且术后并发症少,对免疫功能的影响较小,适合临床上应用。更多还原

【Abstract】 Objective To investigate the short-term clinical efficacy and immune level of laparoscopic radical gastrectomy for early gastric cancer. Methods The data of 124 patients with early gastric cancer from January 2016 to December 2018 were retrospectively analyzed, and they were divided into laparoscopic surgery group and open surgery group, with 62 patients in each group.SPSS21.0 statistical software was used to analyze the data. Perioperative indicators and immunological indicators were represented by■, and independent t-test was performed. The clinical treatment effect was analyzed by rank sum test, the complication rate was tested by χ~2 test, and P<0.05 was considered statistically significant.Results The intraoperative blood loss of patients in the endoscopic group was less than that in the open group, while the operative time, anal exhaust time, out-of-bed activity time, feeding time and postoperative hospital stay were shorter than those in the control group(P<0.05). The incidence of total adverse reactions(9.7%) was lower than that in the open group(25.8%). After treatment, the hs-CRP, IL-6 and TNF-α values of the two groups were increased, while those of the endoscopic group were lower than those of the open group, with statistically significant differences(P<0.05). Conclusion Laparoscopic radical gastrectomy is superior to open radical gastrectomy in the treatment of patients with early gastric cancer, with fewer postoperative complications and less impact on immune function, so it is suitable for clinical application.更多还原