【摘要】 目的探讨氢质子核磁波谱(H1-MRS)检查对儿童热性惊厥(FS)的脑实质异常的检测效率,及其用于预测临床预后的价值。方法选择中山市人民医院普通儿科自2017年3月至2018年5月收治的38例FS患儿作为研究对象,所有患儿均进行颅脑MRI及H1-MRS检查,比较MRI和H1-MRS检查对FS患儿颅内异常检出效率差异。根据H1-MRS结果计算代谢物质氮-乙酰天门冬氨酸(NAA)/[肌酸(Cr)+磷酸肌酸(Cho)]、NAA/Cr、NAA/Cho值,然后根据患儿出现临床不良预后情况分为有不良临床预后组和无不良临床预后组,比较2组患儿间NAA/(Cr+Cho)、NAA/Cr、NAA/Cho值差异,并分析其对预后的评估价值。结果 38例FS患儿中,MRI检出颅脑异常情况有23例,H1-MRS检出颅脑异常情况有32例,异常情况检出率比较差异具有统计学意义(χ~2=5.330,P=0.021)。13例FS患儿出现不良临床预后,有不良临床预后组患儿中表现为复杂型的比率高于无不良临床预后组,差异有统计学意义(P<0.05)。有不良临床预后组患儿的NAA/(Cr+Cho)、NAA/Cr、NAA/Cho值均小于无不良临床预后组,差异有统计学意义(P<0.05)。绘制NAA/(Cr+Cho)、NAA/Cr、NAA/Cho值对预测不良临床预后ROC曲线,其相应的曲线下面积分别为0.848、0.774、0.797。结论 H1-MRS检查对FS患儿脑实质异常的检出率高于MRI检查,且H1-MRS结果计算所得的NAA/(Cr+Cho)、NAA/Cr、NAA/Cho值在FS患儿中显著降低,其中,NAA/(Cr+Cho)值对患儿的预后具有较好的预测价值。更多还原

【Abstract】 Objective To investigate the efficiency of hydrogen proton nuclear magnetic resonance spectroscopy(H1-MRS) in detection of cerebral parenchymal abnormalities, and the predict the value of clinical prognosis in children with febrile seizures(FS). Methods Thirty-eight children with FS given treatments from March 2017 to May 2018 in general pediatrics department of Zhongshan City People Hospital were selected as research objects. All children were examined by brain MRI and H1-MRS, and the values of the metabolites N-acetylaspartic acid/(creatine +Creatine phosphate) [NAA/(Cr +Cho)], NAA/Cr and NAA/Cho were calculated according to the results of H1-MRS. Then, the differences in NAA/(Cr+Cho), NAA/Cr and NAA/Cho values between the children with and without poor clinical prognosis were compared according to the clinical poor prognosis of the children. The prognostic value of NAA/(Cr+Cho), NAA/Cr and NAA/Cho values were analyzed. Results Among the 38 children with FS, 23 craniocerebral abnormalities cases were detected by MRI and 32 craniocerebral abnormalities cases were detected by H1-MRS, there was a statistically difference( χ~2=5.330, P=0.021).Of the 38 children with FS, 13 had poor clinical prognosis and 25 had no poor clinical prognosis, the rate of complex type in the group with poor clinical prognosis was higher than that in the group without poor clinical prognosis, and there was a statistically difference(P <0.05). NAA/(Cr +Cho), NAA/Cr and NAA/Cho in the group with poor clinical prognosis were all lower than those in the group without poor clinical prognosis, showing statistically significant differences(P <0.05). The ROC curve of NAA/(Cr +Cho), NAA/Cr and NAA/Cho for predicting poor clinical prognosis was drawn, and the corresponding area under the curve(ACU) was 0.848, 0.774 and 0.797, respectively. Conclusion The detection rate of brain parenchymal abnormalities by H1-MRS examination was higher than that by MRI examination,and the NAA/(Cr+Cho), NAA/Cr and NAA/Cho values calculated by H1-MRS results were significantly reduced in children with thermal convulsion. Among them, NAA/(Cr+Cho) values were of good predictive value for the prognosis of the children.更多还原