【摘要】 目的探讨放疗前外周血中性粒细胞和淋巴细胞比值(NLR)与鼻咽癌预后的相关性。方法选取2005年1月至2013年3月间南京医科大学第二附属医院收治的105例新发鼻咽癌患者,分析NLR对鼻咽癌总生存时间(OS)的影响及NLR与年龄、性别和TNM分期的关系。结果患者外周血NLR平均值为(2. 82±0. 24),NLR与鼻咽癌患者T分期、N分期和M分期有关,其中T3+T4、N2+N3和M1期患者,NLR明显高于T1+T2、N0+N1和M0期(均P <0. 05),说明分期越晚,NLR越高。NLR与性别和年龄无关(P> 0. 05)。NLR、T分期、N分期和M分期与鼻咽癌的预后均呈负相关。即NLR>3、TNM分期越晚,患者OS越短(均P <0. 05)。NLR和TNM分期是影响鼻咽癌患者预后的独立危险因素(P <0. 05)。结论治疗前NLR升高是影响鼻咽癌预后的不良因素,为预测鼻咽癌的预后提供了新方法。更多还原

【Abstract】 Objective To investigate the relationship between neutrophil to lymphocyte ratio( NLR) in peripheral blood and prognosis in patients with nasopharyngeal cancer before radiotherapy.Methods A total of 105 patients with newly diagnosed nasopharyngeal cancer were selected at The Second Affiliated Hospital of Nanjing Medical University between January 2005 and March 2013. The effect of NLR on overall survival( OS) and the relationship with age,gender and tumor,node,metastasis( TNM) staging was analyzed. Results The average level of NLR was 2. 82 ± 0. 24 suggesting NLR was associated with T stage,N stage,and M stage( all P < 0. 05). NLR was higher in patients with stage T3 + T4,N2 + N3 and M1 than in patients with stage T1 + T2,N0 + N1 and M0. Moreover,it revealed that the higher the stage,the greater the NLR was. However,NLR was not associated with gender( P > 0. 05). NLR and T,N and M stage were negatively associated with the prognosis of nasopharyngeal cancer( all P < 0. 05). The more advanced the T,N and M stage and NLR > 3,the shorter the OS was( all P < 0. 05). NLR was an independent factor influencing the prognosis in patients with nasopharyngeal carcinoma( P < 0. 05). Conclusion Before treatment,increased NLR is an adverse factor influencing the prognosis of nasopharyngeal carcinoma,which provides a new method for evaluating the prognosis of nasopharyngeal carcinoma.更多还原