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Astrocyte and ions metabolism during epileptogenesis:A review for modeling studies

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【Author】 Meng-Meng Du;Jia-Jia Li;Zhi-Xuan Yuan;Yong-Chen Fan;Ying Wu;State Key Laboratory for Strength and Vibration of Mechanical Structures, Xi’an Jiaotong University;School of Aerospace Engineering, Xi’an Jiaotong University;National Demonstration Center for Experimental Mechanics Education, Xi’an Jiaotong University;

【通讯作者】吴莹;

【机构】 State Key Laboratory for Strength and Vibration of Mechanical Structures, Xi’an Jiaotong University； School of Aerospace Engineering, Xi’an Jiaotong University； National Demonstration Center for Experimental Mechanics Education, Xi’an Jiaotong University；

【摘要】 As a large group of cells in a central nervous system, astrocytes have a great influence on ion and energy metabolism in a nervous system. Disorders of neuronal ion and energy metabolism caused by impaired astrocytes play a key role in the pathogenesis of epilepsy. This paper reviews the existing computational models of epileptogenesis resulting from impaired astrocytes and presents several open perspectives with regard to ion and energy metabolism-induced epileptogenesis in a neuron-astrocyte-capillary coupled model.更多还原

【Abstract】 As a large group of cells in a central nervous system, astrocytes have a great influence on ion and energy metabolism in a nervous system. Disorders of neuronal ion and energy metabolism caused by impaired astrocytes play a key role in the pathogenesis of epilepsy. This paper reviews the existing computational models of epileptogenesis resulting from impaired astrocytes and presents several open perspectives with regard to ion and energy metabolism-induced epileptogenesis in a neuron-astrocyte-capillary coupled model.更多还原

【关键词】 epileptogenesis； astrocyte； potassium； glutamate；
【Key words】 epileptogenesis； astrocyte； potassium； glutamate；

【基金】 Project supported by the National Natural Science Foundation of China(Grant No.11772242)

【文献出处】 Chinese Physics B ,中国物理B , 编辑部邮箱 ,2020年03期

【分类号】R742.1
【被引频次】2
【下载频次】43

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