【摘要】 骨关节炎是一种常见的慢性退行性病变。现有研究表明,软骨下骨病变在骨关节炎的发生发展过程中起着重要作用。本文阐述骨关节炎软骨下骨的病理改变及其在骨关节炎发病机制中的作用,同时对以软骨下骨为治疗靶点的相关研究进展进行综述,从而为研究骨关节炎发病机制、开发治疗药物提供参考依据。更多还原

【Abstract】 Osteoarthritis is a most common chronic degenerative disease. Current studies have shown that subchondral bone lesions play important roles in the occurrence and development of osteoarthritis. In this paper,the pathological changes of subchondral bone and theirs roles in pathogenesis of osteoarthritis were discussed, the related research progress of subchondral bone as a therapeutic target were reviewed, so as to provide references for exploring the pathogenesis of osteoarthritis and developing treatment drugs.更多还原