【摘要】 目的探讨宫颈小细胞神经内分泌癌(SCCC)的临床病理特征及免疫组化表达特点。方法收集深圳市宝安区人民医院2006年5月～2020年3月收治的5例SCCC患者,采用光镜、免疫组化方法对其进行研究。结果 5例SCCC患者组织学显示肿瘤细胞小而圆或葵花子样,胞质稀少,核仁不易见,瘤细胞镶嵌样巢团状生长。免疫组化法显示5例患者均至少表达2种以上神经内分泌标志物[突触素(Syn)、嗜铬素A(CgA)和CD56],2例弥漫表达甲状腺转录因子1(TTF-1),5例CD117均阴性。结论 SCCC具有独特的临床病理特征及免疫组化特点,免疫组化在诊断及鉴别诊断中具有重要意义。SCCC特定表达一项以上神经内分泌标志物,TTF-1在原发SCCC和非小细胞癌宫颈转移的鉴别诊断中没有意义,CD117在二者的鉴别中有一定意义。更多还原

【Abstract】 Objective To investigate the clinicopathological and immunohistochemical features of small cell neuroendocrine carcinoma of the cervix(SCCC). Methods A total of 5 cases of SCCC patients were collected and studied by light microscope and immunohistochemistry from May 2006 to March 2020 in Bao′an District People′s Hospital in Shenzhen City. Results The histology of 5 cases showed that the tumor cells were small and round or sunflower-like, the cytoplasm was sparse, the nucleolus was not easy to be seen, and the tumor cells grew in mosaic-like nests. Immunohistochemistry showed that 5 cases expressed at least 2 kinds of neuroendocrine markers(Syn, CGA and CD56), 2 cases diffusely expressed TTF-1, 5 cases of CD117 were negative. Conclusion SCCC has unique clinicopathologic and immunohistochemical features, and immunohistochemistry plays an important role in the diagnosis and differential diagnosis. SCCC specifically expresses more than one neuroendocrine marker, TTF-1 has no significance in the differential diagnosis of cervical metastasis between primary SCCC and non-small cell carcinoma, CD117 has some significance in the differential diagnosis of both.更多还原