【摘要】 目的比较取卵后不同时间冻融胚胎移植的妊娠结局,探讨最早的冻融胚胎移植时机。方法回顾性分析2018年1月1日～6月30日于山西省妇幼保健院生殖医学中心行体外受精胚胎移植(IVF-ET)助孕的患者,将符合本研究纳入及排除标准的患者根据冻融胚胎移植(FET)时机分为两组,A组(75例,取卵后第1个月经周期行FET)和B组(165例,卵巢恢复至超促排卵前水平后行FET)。比较两组患者的卵巢过度刺激综合征(OHSS)分级、内膜准备、妊娠结局。结果两组患者取卵术后OHSS分级比较,差异无统计学意义(P>0.05)。A组患者的雌二醇片使用天数短于B组,雌二醇片使用剂量少于B组,差异有统计学意义(P<0.01);A组患者移植日卵巢体积大于B组,差异有统计学意义(P<0.01)。两组患者的临床妊娠率、胚胎种植率、双胎率、早期流产率、晚期流产率、早产率、分娩率比较,差异无统计学意义(P>0.05)。结论取卵术后OHSS分级为无、轻、中度患者,取卵术后第1个月经周期进行FET,不影响患者的妊娠结局。更多还原

【Abstract】 Objective To compare the pregnancy outcomes of frozen-thawed embryo transfer at different times after oocyte retrieval, and to explore the earliest transplanting time for frozen-thawed embryo transfer. Methods Retrospective analysis of patients who received in vitro fertilization embryo transfer(IVF-ET) at the Reproductive Medicine Center of Women Health Center of Shanxi from January 1 to June 30, 2018 was conducted. Patients who met the inclusion/exclusion criteria of this study were divided into two groups according to the timing of frozen-thawed embryo transfer(FET), with 75 patients in group A who were given FET at the first menstrual cycle after oocyte retrieval, and 165 patients in group B who were given FET after ovaries recovered to the level before superovulation. Ovarian hyperstimulation syndrome(OHSS) classification, endometrial preparation and pregnancy outcomes were compared between the two groups. Results There was no significant difference in OHSS classification between the two groups after oocyte retrieval(P>0.05). The days of using Estradiol Tablets in group A was shorter than that in group B, and the dosage of Estradiol Tablets was less than that in group B, the differences were statistically significant(P <0.01). The ovarian volume in group A was larger than that in group B on the day of transplantation, with statistically significant difference(P<0.01).There were no significant differences in the clinical pregnancy rate, embryo implantation rate, twin rate, early miscarriage rate, late miscarriage rate, premature birth rate and delivery rate between the two groups(P>0.05). Conclusion FET at the first menstrual cycle after oocyte retrieval does not affect the pregnancy outcomes of patients whose OHSS classification after oocyte retrieval is none, mild and moderate.更多还原