【摘要】 目的评价血清人附睾蛋白4(HE4)、癌抗原125(CA125)和卵巢恶性肿瘤风险模型(ROMA)指数预测子宫内膜癌淋巴结转移的价值。方法回顾性选取2016年1月1日至2020年1月1日在辽宁省肿瘤医院因子宫内膜癌手术的326例患者为研究组,同期于体检中心体检的163名正常人群为对照组,评价血清HE4、CA125和ROMA指数预测淋巴结转移的价值。结果研究组与对照组比较,HE4、CA125、ROMA指数差异均具有统计学意义(P<0.05);无论绝经前后CA125、ROMA指数均与淋巴结转移相关,HE4与绝经前组淋巴结转移相关,HE4、CA125、ROMA指数淋巴结阳性组均高于淋巴结阴性组;绝经前CA125≥69.45 kU/L,绝经后CA125≥21.45 kU/L为淋巴结转移的独立危险因素;CA125预测淋巴结转移的绝经前、后的ROC曲线下面积分别为0.810、0.671;HE4、CA125、ROMA指数评估淋巴结转移的阴性预测值大于90%。结论 HE4、CA125、ROMA指数均可准确评估子宫内膜癌及淋巴结转移情况。CA125比HE4、ROMA指数评估淋巴结转移的准确性高。更多还原

【Abstract】 Objective To evaluate the value of serum HE4,CA125 and ROMA in predicting lymph node metastasis in endometrial carcinoma.Methods We recruited 326 EC patients who underwent surgery in Liaoning Cancer Hospital between January 1,2016 and January 1,2020 as the observation group;163 normal people who visited the physical examination center during the same period were selected as the control group.Finally we use the results of those two groups to evaluate the predictive value of serum levels of HE4,CA125 and ROMA in lymph node metastasis.Results The differences in HE4,CA125 and ROMA values between the observation group and the control group were statistically significant(P<0.05).Whether before menopause or after,the serum level of HE4 and CA125 was significantly correlated with lymph node metastasis,while HE4 was associated with lymph node metastasis in the premenopausal group.HE4,CA125 and ROMA values in lymph node positive group "were all higher than those in negative group.Premenopausal CA125≥69.45 kU/L and postmenopausal CA125≥21.45 kU/L were the independent risk factors for lymph node metastasis;the area under the pre-menopausal and post-menopausal ROC curve of lymph node metastasis predicted by CA125 was 0.810 and 0.671.The negative predictive values of HE4,CA125 and ROMA in assessing lymph node metastasis were greater than 90%.Conclusion HE4,CA125 and ROMA values can accurately assess endometrial carcinoma and lymph node metastasis.CA125 is more accurate than HE4 and ROMA in evaluating lymph node metastasis.更多还原