【摘要】 布鲁氏菌病是全球常见的危害人类与动物的主要的人畜共患病。目前,我国人群新发布病呈上升趋势,且尚无针对人类布病的有效疫苗。布鲁氏菌感染宿主后,可通过调节自身基因的表达调控适应宿主巨噬细胞内环境,保证其静息存活然后大量复制,从而阻碍了布病的有效药物治疗。本综述重点介绍了布鲁氏菌生物种及其宿主范围、动物感染模型及疫苗研究等问题,分析了布鲁氏菌宿主胞内存活的机制,为布病防控提出了下一步研究的建议。更多还原

【Abstract】 Brucellosis remains one of the most common zoonosis globally,affecting both animal and human health.In China,the number of human brucellosis cases continues to grow due to the lack of an effective licensed vaccine. After infection by Brucella,the bacteria can adapt to the host macrophage internal environment through regulating the expression of its own genes,ensuring its resting survival and subsequent replication,which hinders effective therapeutics for brucellosis. This review focuses on the issues of Brucella species and its host range,animal infection models and vaccine investigation,summarizes the mechanisms of Brucella intracellular survival within the host,and proposes key points for the prevention and control of brucellosis.更多还原