【摘要】 目的探讨阿司匹林与低分子肝素二联疗法对胎儿生长受限(FGR)结局的影响及安全性。方法将110例2017年4月1日-2019年5月31日期间收治的FGR孕妇按照随机数字表法分为2组,每组55例,对照组给予低分子肝素钠皮下注射,治疗组在对照组治疗基础上给予肠阿司匹林溶片口服。比较2组胎儿发育情况、脐动脉血流指标、羊水指数(AFI)和生物物理评分(BPS),并比较2组母婴结局。结果治疗组孕妇宫高及胎儿头围、双顶径、腹围、股骨长增加情况优于对照组(P<0.01),AFI、BPS高于对照组(P<0.01);PI、RI、S/D值低于对照组(P<0.01);治疗组新生儿胎龄、体重、Apgar评分均高于对照组(P<0.05),早产儿、足月小样儿发生率低于对照组(P<0.05),妇妊娠合并症发生率低于对照组(P<0.05),差异有统计学意义。2组用药期间未发生药物过敏反应和血小板减少、凝血功能障碍等并发症。结论阿司匹林与低分子肝素二联疗法可改善脐动脉血液循环,促进胎儿发育,改善母儿结局,治疗FGR安全性好。更多还原

【Abstract】 Objective To investigate the Effect and safety analysis of aspirin combined with low molecular weight heparin on outcomes of fetal growth restriction(FGR). Methods 110 pregnant women with FGR weredivided into two groups according to the digital random table method, with 55 cases in each group. The control group were given subcutaneous injection of low molecular weight heparin sodium. The treatment group were givenaspirin tablets orally basedon the treatment of the control group. The fetal development, umbilical artery blood flow index, amniotic fluid index(AFI) and biophysical score(BPS) were compared between the two groups, and the maternal and infant outcomes were compared between the two groups. Results The increase of uterine height, fetal head circumference, biparietal diameter, abdominal circumference and femoral length of the treatment group were better than those of the control group(P<0.1), AFI and BPS were higher than those of the control group(P<0.01), PI, RI and S/D values were lower than those of the control group; The gestational age, weight and Apgar score of the treatment group were higher than those of the control group(P<0.05), and the incidence of premature and full-term infants was lower than those of the control group(P<0.05). The incidence of pregnancy complications was lower than that of the control group(P<0.05), and the difference was statistically significant. There were no drug allergic reactions, thrombocytopenia, coagulation dysfunction and other complications in the two groups. Conclusions The combination therapy of aspirin and low molecular weight heparin could improve umbilical artery blood circulation, promote fetal development, improve maternal and fetal outcomes, so it hada good safety in the treatment of FGR.更多还原