【摘要】 目的探讨雷珠单抗玻璃体腔注射联合小梁切除术(NPTS)+视网膜光凝术(PRP)治疗新生血管性青光眼(NVG)的疗效,为临床治疗提供指导。方法选择我院2013年1月～2018年1月接诊的60例NVG患者进行研究。按照治疗方法的不同将患者分为对照组和观察组。对照组接受NPTS+PRP治疗,观察组接受雷珠单抗玻璃体腔注射联合NPTS+PRP治疗。比较两组治疗效果,术前、术后1、3、6个月的眼压情况及术后并发症。结果观察组的治疗总有效率(96.67%)明显高于对照组(80.00%),差异有统计学意义(P<0.05)。术前两组眼压相比差异无统计学意义(P>0.05);术后1、3、6个月,观察组眼压均明显低于对照组,差异有统计学意义(P<0.05)。观察组并发症总发生率(6.67%)明显低于对照组(30.00%),差异有统计学意义(P<0.05)。结论雷珠单抗玻璃体腔注射联合NPTS+PRP治疗NVG的疗效显著,能够明显改善患者的眼压情况,降低并发症发生率,值得临床上应用及推广。更多还原

【Abstract】 Objective To explore the efficacy of intravitreal injection of ranibizumab combined with trabeculectomy(NPTS)+retinal photocoagulation(PRP) in the treatment of neovascular glaucoma(NVG), and to provide guidance for clinical treatment. Methods A total of 60 patients with NVG who were admitted to our hospital from January 2013 to January 2018 were selected for study. According to different treatment methods, patients were divided into control group and observation group. The control group received NPTS+PRP treatment, and the observation group received ranibizumab intravitreal injection combined with NPTS+PRP treatment. The treatment effects, intraocular pressure, and postoperative complications were compared between the two groups before surgery, and 1, 3, and 6 months after surgery. Results The total effective rate of treatment in the observation group(96.67%) was significantly higher than that in the control group(80.00%), and the difference was statistically significant(P<0.05). Before surgery, there was no significant difference in intraocular pressure between the two groups(P>0.05). The intraocular pressure in the observation group was significantly lower than that in the control group at 1, 3, and 6 months after operation, and the difference was statistically significant(P<0.05). The total incidence of complications in the observation group(6.67%) was significantly lower than that in the control group(30.00%), and the difference was statistically significant(P <0.05). Conclusion Intravitreal injection of ranibizumab combined with NPTS+PRP in the treatment of NVG has significant effect. It can significantly improve the intraocular pressure of patients and reduce the incidence of complications. It is worthy of clinical application and promotion.更多还原