【摘要】 目的探讨贵阳市老年人群维生素D水平及与老年性疾病的相关性。方法收集2013年4月～2019年6月在贵阳市第一人民医院进行过维生素D检查的老年患者资料,共5913例,检测患者血清25-羟维生素D₃。检测结果分为维生素D缺乏、不足、正常情况,按临床诊断分组,分为高血压组、心力衰竭组、脑卒中组、糖尿病组及健康对照组5组,结合临床资料进行回顾性分析,探讨贵阳市老年人群维生素D水平及与老年性疾病的相关性。结果 25-羟维生素D₃平均水平为20.797 ng/mL,其中25-羟维生素D₃缺乏（<20 ng/mL）3137例,占53.03%;维生素D₃不足（20 ng/mL<D₃<30 ng/mL）1722例,占29.13%;维生素D₃正常（>30 ng/mL）1054例,占17.84%。健康正常对照组维生素D₃水平显著高于血压组、心力衰竭组、脑卒中组和糖尿病组（P<0.05）,而高血压组、心力衰竭组、脑卒中组、糖尿病组在血清25（OH）D水平上无统计学差异（P>0.05）,高血压组、心力衰竭组、脑卒中组、糖尿病组不同严重程度间的血清25（OH）D水平具有统计学差异（P<0.05）,病情严重程度越高,血清25（OH）D水平越低,血清25（OH）D水平与高血压、心力衰竭、脑卒中、糖尿病等老年性疾病存在负相关（P<0.05）。结论贵阳市老年人维生素D水平显著低于正常,老年人群维生素D水平与老年性疾病明显相关,适量补充维生素D有可能成为预防和治疗老年性疾病的有效手段。更多还原

【Abstract】 Objective To investigate the relationship between vitamin D levels and senile diseases in the elderly in Guiyang. Methods A total of 5913 elderly patients who underwent vitamin D examination in Guiyang First People’s Hospital from April 2013 to June 2019 were enrolled. The serum 25-hydroxyvitamin D₃ test results were divided into vitamin D deficiency, lack and normality. According to the clinical diagnosis, the patients were divided into hypertension group, heart failure group, stroke group, diabetes group and healthy control group. The clinical data were retrospectively analyzed. The relevance of vitamin D level and senile diseases in the elderly in Guiyang was explored. Results The average level of 25-hydroxyvitamin D₃ was 20.797 ng/mL, of which there were 3137 cases of 25-hydroxyvitamin D₃ deficiency（<20 ng/mL）, accounted for 53.03%; 1722 cases of vitamin D₃ insufficiency（20 ng/mL<D₃<30 ng/mL）,accounted for 29.13%; and 1054 cases of normal vitamin D₃（>30 ng/mL）, accounted for 17.84%. The level of vitamin D₃ in healthy normal control group was significantly higher than that in hypertension group, heart failure group, stroke group and diabetes group（P<0.05）. There were no significant differences in serum 25（OH）D levels between the hypertension group, the heart failure group, the stroke group, and the diabetes group（P>0.05）. Serum 25（OH）D levels were statistically different between different severity in the hypertension group, the heart failure group, the stroke group, and the diabetes group（P<0.05）. The higher the severity of the disease, the lower the serum 25（OH）D level. There was a negative correlation between the serum 25（OH）D level and senile diseases such as hypertension, heart failure, stroke and diabetes（P<0.05）. Conclusion Vitamin D levels in the elderly in Guiyang are significantly lower than normal. Vitamin D levels in the elderly are significantly associated with senile diseases. Appropriate vitamin D supplementation may be an effective means of preventing and treating senile diseases更多还原