【摘要】 <正>人类肿瘤的动物异种移植模型是肿瘤研究的关键临床前工具。目前最常用的动物移植瘤模型是免疫缺陷小鼠模型。近十年来,由于斑马鱼（Danio rerio）与人类基因组同源性高达70%,个体小,可大规模快速繁殖,胚体透明易于观察,发育前一个月无适应性免疫,以及成本低等原因^[1-2],这种动物模型逐渐更多还原

【Abstract】 Zebrafish is a non-mammalian vertebrate that has gained wide attentions as a novel tumor xenograft model in human cancer research.Compared with common mouse models,zebrafish models possess distinct properties of short research period,high throughput,dynamic visualization of tumor growth in vivo,and low cost.This review outlines the advantages and limitations of zebrafish models,the construction and variety of zebrafish tumor xenograft models,and its applications and prospects in anti-tumor drug development and clinical therapy options for preclinical cancer research and precision medicine.更多还原