【摘要】 目的了解临床药学干预对呼吸内科合理使用抗生素的促进作用。方法纳入我院2017年1月至2018年1月收治的90例呼吸内科疾病患者,根据随机数字表法分为常规组与研究组,各45例。常规组患者使用常规抗生素治疗,未实施临床药学干预;研究组患者在使用常规抗生素治疗基础上实施临床药学干预。比较两组患者满意度;护理前后超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)水平以及药学干预质量评分;患者对药物机制的掌握度、使用抗生素的依从性、对于抗生素存在的不良反应的了解程度评分;抗生素使用不良反应发生率。结果两组患者满意度、护理后hs-CRP、TNF-α、IL-6水平以及药学干预质量评分、患者对药物机制的掌握度、使用抗生素的依从性、对于抗生素存在的不良反应的了解程度评分、抗生素使用不良反应发生率均优于常规组,P<0.05。结论呼吸内科疾病患者在实施常规抗生素治疗基础上应用临床药学干预的效果确切,可有效改善患者的病情,提高患者治疗的依从性,提高患者对抗生素的认知水平,并有效控制机体炎性指标,改善患者的预后。更多还原

【Abstract】 Objective To investigate the promoting effect of clinical pharmaceutical intervention on the rational use of antibiotics in respiratory department. Methods 90 patients with respiratory diseases treated in our hospital from January 2017 to January 2018 were divided into routine group and study group according to the random number table method, 45 cases in each group. Patients in the routine group were treated with routine antibiotics without clinical pharmaceutical intervention, while patients in the study group were treated with clinical pharmaceutical intervention on the basis of routine antibiotic treatment. The satisfaction, the levels of hypersensitive C-reactive protein(hs-CRP), tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and the quality score of pharmaceutical intervention before and after nursing, the scores of patients’ mastery of drug mechanism, compliance with the use of antibiotics, understanding of adverse reactions of antibiotics, and the incidence of adverse reactions of antibiotics were compared between the two groups. Results The satisfaction, the levels of hs-CRP, TNF-α and IL-6, the quality score of pharmaceutical intervention, the patients’ mastery of drug mechanism, the compliance with the use of antibiotics, the score of understanding of the adverse reactions of antibiotics after nursing and the incidence of adverse reactions of antibiotics in the two groups were superior to those in the routine group(P<0.05). Conclusion Clinical pharmaceutical intervention is effective in patients with respiratory diseases on the basis of routine antibiotic treatment, which can effectively improve the patient’s condition, improve the patient’s compliance with treatment, and improve the patient’s cognitive level of antibiotics, and effectively control the inflammatory index of the body and improve the prognosis of the patients.更多还原