【摘要】 目的:探讨银丹心脑通软胶囊联合酒石酸美托洛尔片治疗冠心病心绞痛的临床疗效。方法:选取2015年8月至2018年8月海南省安宁医院收治的冠心病心绞痛患者102例,按照随机数字表法分为对照组和研究组,各51例。对照组患者给予酒石酸美托洛尔片治疗,研究组患者给予银丹心脑通软胶囊联合酒石酸美托洛尔片治疗。比较两组患者临床疗效,血脂指标[三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)]、心功能指标[左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)和左心室射血分数(LVEF)]、血液流变学指标[全血黏度(WBV)、纤维蛋白原(FIB)和血小板黏附率(PAR)]水平及心绞痛发作次数、持续时间的差异,记录两组患者不良反应发生情况。结果:治疗后,研究组患者心绞痛、心电图总有效率明显高于对照组,差异有统计学意义(P<0. 05)。治疗后,两组患者HDL-C、LVEF水平较治疗前明显升高,且研究组患者明显高于对照组;两组患者TG、TC、LDL-C、WBV、FIB、PAR、LVESD及LVEDD水平较治疗前明显降低,且研究组患者明显低于对照组,上述差异均有统计学意义(P<0. 05)。治疗后,两组患者心绞痛发作次数、持续时间均较治疗前明显改善;且研究组患者心绞痛发作次数明显少于对照组,心绞痛持续时间明显短于对照组,差异均有统计学意义(P<0. 05)。研究组、对照组患者不良反应发生率分别为25. 49%(13/51)、17. 65%(9/51),差异无统计学意义(P>0. 05)。结论:银丹心脑通软胶囊联合酒石酸美托洛尔片治疗冠心病心绞痛的疗效确切,可有效改善患者的心功能指标、血液流变学指标及血脂指标水平。更多还原

【Abstract】 OBJECTIVE: To explore the clinical effect of Yindan Xinnaotong soft capsule combined with Metoprolol tartrate tablets in the treatment of coronary heart disease with angina pectoris. METHODS: 102 patients with coronary heart disease with angina pectoris who were admitted to Hainan Provincial Anning Hospital from Aug. 2015 to Aug.2018 were selected and divided into control group and research group via random number table,with 51 cases in each group. The control group was treated with Metoprolol tartrate tablets,while the research group was treated with Yindan Xinnaotong soft capsule combined with Metoproprol tartrate tablets. Differences in clinical efficacy,blood lipid indices[triacylglycerol( TG),total cholesterol( TC),low density lipoprotein cholesterin( LDL-C) and high density lipoprotein cholesterin( HDL-C) ],cardiac function indexs[left ventricular end-systolic dimension( LVESD),left ventricular end-diastolic dimension( LVEDD) and left ventricular ejection fraction( LVEF) ],hemorheology indices[whole blood viscosity( WBV),fibrinogen( FIB) and platelet adhesion rate( PAR) ],frequency and duration of angina pectoris were compared between two groups,and incidences of adverse drug reactions of two groups were recorded. RESULTS: After treatment,the total effective rates of angina and ECG of research group were significantly higher than those of the control group,with statistically significant differences( P<0. 05). After treatment,the levels of HDL-C and LVEF levels in the two groups were significantly higher than those of before treatment,and those of the research group were significantly higher than the control group; the levels of TG,TC,LDL-C,WBV,FIB,PAR,LVESD and LVEDD levels in the two groups were significantly lower than those of before treatment,and those of the research group were significantly lower than the control group,with statistically significant differences( P < 0. 05).After treatment,the frequency and duration of angina pectoris in the two groups were significantly improved compared with that before treatment; the frequency of angina pectoris of research group was significantly less than that of the control group,and the duration of angina pectoris of research group was significantly shorter than that of the control group,with statistically significant differences( P<0. 05). The incidences of adverse drug reactions of research group and control group were respectively 25. 49%( 13/51) and 17. 65%( 9/51),the difference had no statistical significance( P>0. 05). CONCLUSIONS: Yindan Xinnaotong Soft Capsule combined with metoprolol tartrate tablets is effective in the treatment of coronary heart disease with angina pectoris. It can effectively improve cardiac function index,hemorheology index and blood lipid index.更多还原