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姜黄素抗衰老作用及分子机制研究新进展

Recent progress on anti-aging and molecular mechanisms of curcumin

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【作者】 张萌李潭林韬徐东辰龚冬梅

【Author】 ZHANG Meng;LI Tan;LIN Tao;XU Dongchen;GONG Dongmei;Department of Pharmacology, College of Pharmacy, Harbin Medical University;

【通讯作者】 龚冬梅;

【机构】 哈尔滨医科大学药学院药理教研室

【摘要】 姜黄素是从传统中药姜黄中提取的多酚类活性成分,长期作为中药及调味品在国内外广泛使用。因作用靶点多样,具有抗氧化、抗炎、抗动脉粥样硬化、抗肿瘤等多种作用。近年来其抗衰老作用备受研究者关注。本文主要从分子角度总结近5年姜黄素在神经系统、心血管系统及皮肤的抗衰老作用,为药物研发及合理应用提供可借鉴的思路。

【Abstract】 Curcumin is a polyphenolic active ingredient extracted from the traditional Chinese medicine Turmeric,which has been widely used as medicine and seasoning at home and abroad. Due to its multiple targets, it has various effects such as anti-oxidation, anti-inflammation, anti-atherosclerosis, anti-tumor and so on. In recent years, its antiaging effect has attracted much attention from researchers. This review mainly summarizes the anti-aging effects of curcumin on nervous system, cardiovascular system and skin from a molecular perspective in the recent five years, expecting to shed new light on prospective drug discovery and rational application.

【关键词】 姜黄素抗衰老氧化应激炎症
【Key words】 CurcuminAnti-agingOxidative stressInflammation
【基金】 国家自然科学基金资助项目(81202523)
  • 【文献出处】 中国医药导报 ,China Medical Herald , 编辑部邮箱 ,2020年28期
  • 【分类号】R285.5
  • 【被引频次】2
  • 【下载频次】837
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