【摘要】 糖尿病发病涉及多种因素。糖尿病及其慢性并发症可引起全身多器官、多系统损害。自噬是真核生物中高度保守的分解代谢过程,其调节机制十分复杂,涉及许多通路在不同阶段之间的配合。研究发现自噬与糖尿病及其慢性并发症的发生发展密切相关,本文就细胞自噬在糖尿病及其慢性并发症中的调节作用的最新研究进展作一综述。更多还原

【Abstract】 Many factors are involved in the pathogenesis of diabetes mellitus. Diabetes mellitus and its chronic complications can cause damage to multiple organs and systems of the whole body. Autophagy is a highly conservative catabolism process in eukaryotes. Its regulatory mechanism is very complex and involves the coordination of many pathways at different stages. It has been found that autophagy is closely related to the occurrence and development of diabetes mellitus and its chronic complications. In this paper, the latest research progress on the regulatory role of cell autophagy in diabetes and its chronic complications are reviewed.更多还原