【摘要】 骨关节炎是骨科常见的关节疾病,随着人口老龄化加重其患病率也在增加。骨关节炎发病受多因素的影响,包括氧化应激和活性氧的过量产生。这些因素调节细胞内信号传导过程,软骨细胞衰老和细胞凋亡,细胞外基质合成和降解以及滑膜炎症和软骨下骨功能障碍。由于治疗骨关节炎的药物相对较少,本文针对复杂的氧化应激信号通路为治疗骨关节炎提供策略。更多还原

【Abstract】 Osteoarthritis is a common joint disease in orthopedics, and its prevalence is increasing with the aging of population. The pathogenesis of osteoarthritis is influenced by multiple factors, including oxidative stress and excessive production of reactive oxygen species, which regulate intracellular signal transduction, chondrocyte aging and apoptosis,extracellular matrix synthesis and degradation, synovial inflammation and subchondral bone function. Due to relatively few drugs for osteoarthritis, this paper targeting complex oxidative stress signaling pathways could provides strategies for treating osteoarthritis.更多还原