【摘要】 目的探讨甜梦胶囊联合盐酸舍曲林片治疗脑卒中后抑郁症(PSD)的临床效果。方法选取2018年1～11月广州市红十字会医院收治的PSD患者95例为研究对象,按随机数字表法将其分为对照组(47例)和研究组(48例)。对照组给予盐酸舍曲林片治疗,研究组给予甜梦胶囊联合盐酸舍曲林片治疗。比较两组临床疗效、血清5-羟色胺(5-HT)、脑源性神经营养因子(BDNF)水平、抑郁焦虑状况、睡眠质量及不良反应。结果研究组临床总有效率高于对照组(P <0.05);治疗后研究组5-HT、BDNF水平高于对照组(P <0.05);治疗后研究组汉密尔顿抑郁量表、汉密尔顿焦虑量表评分及匹兹堡睡眠质量指数量表评分低于对照组(P <0.05);两组不良反应发生率比较差异无统计学意义(P> 0.05)。结论甜梦胶囊联合盐酸舍曲林片治疗PSD患者的临床效果较好,可改善抑郁焦虑状况,提高睡眠质量,不良反应低,值得临床推广。更多还原

【Abstract】 Objective To explore the clinical efficacy of Tian Meng Capsules combined with Sertraline Hydrochloride Tablets in the treatment of post-stroke depression(PSD). Methods Ninety-five patients with PSD who were admitted to Guangzhou Red Cross Hospital from January to November 2018 were selected as subjects. The patients were divided into control group(47 cases) and study group(48 cases) by random number table method. The control group was given Sertraline Hydrochloride Tablets, the study group was given Tian Meng Capsules combined with Sertraline Hydrochloride Tablets. The clinical efficacy, serum 5-hydroxytryptamine(5-HT), brain-derived neurotrophic factor(BDNF), depression and anxiety, sleep quality and adverse reactions were compared between the two groups. Results The total clinical effective rate in the study group was higher than that in the control group(P < 0.05). After treatment, the levels of 5-HT and BDNF in the study group were higher than those in the control group(P < 0.05). The scores of Hamilton depression scale, Hamilton anxiety scale and Pittsburgh sleep quality index in the study group were lower than those in the control group(P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P > 0.05). Conclusion Tian Meng Capsules combined with Sertraline Hydrochloride Tablets is effective in the treatment of PSD. It can improve depression and anxiety, and enhance sleep quality, the adverse reactions are low. It can be widely used in clinic.更多还原