【摘要】 神经病理性疼痛(NPP)是当今社会中十分常见的一种症状,引起神经病理性疼痛的具体机制还不清楚,且尚未出现能够有效治疗神经病理性疼痛的药物。近年来研究者发现瞬时感受器电位(TRP)通道参与细胞内多种反应,其中瞬时感受器电位香草酸受体1(TRPV1)与神经病理性疼痛关系最为密切,可能是治疗神经病理性疼痛的重要靶点之一。文章综述了神经病理性疼痛的概况与TRP通道家族的组成与功能,重点阐述了TRPV1抑制剂作为靶向药物在神经病理性疼痛中的研究进展,旨在为神经病理性疼痛的药物治疗提供新的研究方向。更多还原

【Abstract】 Neuropathic pain(NPP)is a very common symptom in current society. However,the mechanism of NPP is still unclear,and there are no effective drugs which can effectively treat NPP. In recent years,Transient Receptor Potential(TRP)channels are found to be involved in multiple intracellular responses.Transient Receptor Potential Vanilloid 1,TRPV1 isclosely related to NPP,which makes its inhibitors as important drugs targeted for NPP. This article summarize the overview of NPP and the composition and function of the TRP channel family. The focus is on the research progress of TRPV1 inhibitors as targeted drugs in neuropathic pain,and provides a new research direction for drug therapy of neuropathic pain.更多还原