【摘要】 目的探究白球蛋白比值(AGR)、补体C3、C4在系统性红斑狼疮(SLE)合并脑血管病中的检测价值。方法选取本院2018年1月至2019年10月SLE合并脑血管疾病患者136例作为研究组,单纯SLE患者136例作为对照组。比较两组血清AGR、补体C3、C4水平,评价上述指标对SLE合并脑血管病的诊断价值,并对比研究组不同疗效患者血清AGR、补体C3、C4水平,分析上述指标与SLE合并脑血管疾病患者疗效的关系,随访28 d,采用卡普兰-迈耶曲线分析SLE合并脑血管疾病患者生存情况。结果研究组血清AGR、补体C3、C4水平低于对照组(P<0.05);血清AGR、补体C3、C4联合诊断SLE合并脑血管病的曲线下面积(AUC)为0.862,大于各指标单独诊断的AUC,联合诊断的截断值诊断敏感度为74.26%,特异度为86.76%;SLE合并脑血管病患者疗效与血清AGR、补体C3、C4表达水平显著相关(P<0.05);研究组血清AGR、补体C3、C4高表达患者生存率高于低表达患者(P<0.05)。结论血清AGR、补体C3、C4表达水平异常降低可增加SLE患者并发脑血管疾病风险,降低生存率,且与患者疗效显著相关,可辅助临床诊断SLE合并脑血管疾病,具有较高应用价值。更多还原

【Abstract】 Objective To explore the detection value of albumin-to-globulin ratio(AGR),C3 and C4 in cerebrovascular disease in patients with systemic lupus erythematosus(SLE). Methods 136 cerebrovascular disease patients with SLE from January 2018 to October 2019 were selected as the study group,and 136 patients with SLE only were used as the control group. The serum AGR,complement C3,C4 levels of the two groups were measured and compared. The diagnostic value was evaluated. The relationship between the serum level of AGR or C3/C4 and the efficacy of cerebrovascular disease in patients with SLE was analyzed. Followed up for 28 days,Kaplan-Meyer curve was used to analyze the survival of cerebrovascular disease patients with SLE. Results The levels of serum AGR,complement C3 and C4 in the study group were lower than those in the control group(P<0.05). The area under the curve(AUC)of the combined diagnosis of serum AGR,complement C3,C4 and SLE combined with cerebrovascular disease was 0.862,which was greater than the AUC of AGR,complement C3 and C4 alone. The cutoff value of the combined diagnosis was74.26% in sensitivity and 86.76% in specificity. The efficacy of SLE patients with cerebrovascular disease was significantly correlated with the serum levels ofAGR,complement C3 and C4(P<0.05). The survival rate of patients with high levels of serum AGR,complement C3 and C4 in the study group was higher than those of patients with low lovels(P<0.05). Conclusion Down-regulation of serum levels of AGR,complement C3 and C4 can increase the risk of cerebrovascular disease in SLE patients and reducing the survival rate. Therefore,it can assist clinical diagnosis of cerebrovascular disease in patients with SLE patients SLE.更多还原