【摘要】 目的探讨正电子发射断层扫描PET/CT在帕金森病患者早期诊断中的应用价值。方法选取我院2015年6月～2018年9月收治的原发性早期帕金森患者25例记为研究组,另选除外神经系统相关疾病的同期检查者25例记为对照组,均采用PET/CT进行扫描诊断,比较各组双侧尾状核和前后壳核11C-CFT摄取值。结果对照组双侧基底节显示清楚,尾状核和壳核均匀分布,而研究组双侧壳核11C-CFT摄取少于对照组,其中发病对侧减少较多,而发病同侧相对较少,两组患者两侧尾状核摄取均没有显著减少。通过ROI分析,研究组双侧尾状核摄取值与对照组比较,差异无统计学意义(P>0.05),而前壳核和后壳核摄取值低于对照组,差异有统计学意义(P<0.05);早期偏侧PD患者发病同侧、对侧和对照组双侧尾状核摄取值两两之间比较,差异无统计学意义(P>0.05),而前后壳核三组间两两比较,差异有统计学意义(P<0.05)。结论 PET/CT显像技术能够早期分辨出双侧尾状核和前后壳核中多巴胺(DA)转运体的不同分布,在帕金森病患者早期诊断中具有重要的应用价值。更多还原

【Abstract】 Objective To explore the application value of PET/CT in the early diagnosis of Parkinson’s disease patients.Methods 25 patients with primary early Parkinson’s who were admitted to our hospital from June 2015 to September 2018 were selected as the study group, and 25 patients with concurrent examinations except for neuro-related diseases were selected as the control group. All were treated with PET/CT scan diagnosis, compare the11 C-CFT uptake values of bilateral caudate nucleus and putamen in each group.Results The bilateral basal ganglia of the control group were clearly displayed, and the caudate nucleus and putamen were evenly distributed, while the11 C-CFT uptake of the bilateral putamen in the study group was less than that of the control group. The contralateral side of the disease decreased more, and the disease on the ipsilateral side was relatively less.The caudate nucleus uptake on both sides of the two groups did not significantly decrease. Through ROI analysis, the bilateral caudate nucleus uptake value of the study group was not statistically different from that of the control group(P >0.05), while the anterior putamen and posterior putamen uptake were lower than the control group,the difference was statistically significant(P<0.05); there was no significant difference in the uptake values of the bilateral caudate nucleus between the ipsilateral, contralateral and control groups in patients with early hemilateral PD( P>0.05), while the three groups before and after putamen Pairwise comparison, the difference was statistically significant( P<0.05).Conclusion PET/CT imaging technology could early distinguish the different distribution of dopamine(DA) transporters in the bilateral caudate nucleus and the anterior and posterior putamen, which had important application value in the early diagnosis of Parkinson’s disease.更多还原