【摘要】 目的观察黄葵胶囊联合醋酸泼尼松治疗原发性肾病综合征临床疗效。方法选取2018年8月～2019年8月在我院诊治的96例原发性肾病综合征患者为研究对象,采用随机数字表法分为对照组和观察组,各48例。对照组采用醋酸泼尼松治疗,观察组在醋酸泼尼松治疗基础上给予黄葵胶囊治疗,比较两组临床总有效率、治疗前后肾功能指标[尿素氮(BUN)、24h尿蛋白定量、血肌酐(SCr)]、血脂指标[胆固醇(CHO)、甘油三酯(TG)、低密度脂蛋白(LDL)]、血浆白蛋白以及临床不良反应(失眠、高血糖、药源性高血压、恶心)发生情况。结果观察组临床治疗总有效率为93.75%,高于对照组的81.25%,差异有统计学意义(P<0.05);治疗后两组BUN、24h尿蛋白定量、SCr、CHO、TG、LDL均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后两组血浆白蛋白均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组临床不良反应发生率为8.33%,与对照组的10.41%比较,差异无统计学意义(P>0.05)。结论黄葵胶囊联合醋酸泼尼松治疗原发性肾病综合征有效率高,患者肾功能改善明显,可一定程度降低血脂,且临床不良反应少,联合治疗安全可靠。更多还原

【Abstract】 Objective To observe the clinical efficacy of Huangkui capsule combined with prednisone acetate in the treatment of primary nephrotic syndrome.Methods A total of 96 patients with primary nephrotic syndrome who were diagnosed and treated in our hospital from August 2018 to August 2019 were selected as the research objects. They were divided into control group and observation group by random number table method, with48 cases in each group. The control group was treated with prednisone acetate, and the observation group was treated with Huangkui capsules on the basis of prednisone acetate treatment. The total clinical effective rate and renal function indexes before and after treatment were compared between the two groups [urea nitrogen(BUN), 24 h urine protein quantification, Serum creatinine(SCr)], blood lipid indexes [cholesterol(CHO), triglycerides(TG), low-density lipoprotein(LDL)], plasma albumin, and clinical adverse reactions(insomnia, hyperglycemia, drug-induced hypertension, nausea)occurs.Results The total effective rate of clinical treatment in the observation group was 93.75%, which was higher than 81.25% in the control group,the difference was statistically significant(P<0.05); after treatment, the two groups had low BUN, 24 h urine protein quantification, SCr, CHO, TG,and LDL before treatment, and the observation group was lower than the control group, the difference was statistically significant(P <0.05); after treatment, the plasma albumin of the two groups was higher than before treatment, and the observation group was higher than the control group, the difference was statistically significant(P <0.05); The incidence of clinical adverse reactions in the observation group was 8.33%, which was not statistically significant compared with 10.41% in the control group(P>0.05).Conclusion Huangkui capsule combined with prednisone acetate had a high effective rate in the treatment of primary nephrotic syndrome. The patient’s renal function was improved significantly, blood lipids could be reduced to a certain extent, and clinical adverse reactions were few. The combined treatment was safe and reliable.更多还原