【摘要】 目的分析阿奇霉素在儿科抗感染中发生不良反应的危险因素。方法选择2018年5月～2019年5月在我院诊治采用阿奇霉素治疗的96例患儿为研究对象,比较不同给药途径不良反应发生率,分析患儿年龄、体质量、用药频率是否合理、适应症选择是否合理、用药剂量是否合理、给药浓度是否合理及疗程对发生不良反应的影响。结果口服阿奇霉素患儿不良反应发生率为10.86%,低于静脉注射阿奇霉素的20.00%,差异有统计学意义(P<0.05);不良反应组与未发生不良反应组年龄、体质量、用药频率、适应证选择、用药剂量、给药浓度、治疗疗程比较,差异有统计学意义(P<0.05); Logistic回归分析显示,用药剂量、给药浓度、用药频率、适应证选择不合理为不良反应发生独立危险因素(P<0.05)。结论在儿科抗感染治疗中阿奇霉素应尽量选择口服给药方式,严格控制给药剂量、浓度及适应证,并尽量缩短用药疗程,以降低阿奇霉素不良反应的发生率。更多还原

【Abstract】 Objective To analyze the risk factors of adverse reactions of azithromycin in pediatric anti-infection.Methods 96 children who were treated with azithromycin in our hospital from May 2018 to May 2019 were selected as the research objects. The incidence of adverse reactions of different administration routes was compared, and the age, weight, and frequency of medication of the children were analyzed whether they were reasonable. Whether the selection of indications is reasonable, whether the dosage of the drug is reasonable, whether the concentration of the drug is reasonable, and the influence of the course of treatment on the occurrence of adverse reactions.Results The incidence of adverse reactions in children with oral azithromycin was 10.86%, which was lower than 20.00% of intravenous azithromycin,the difference was statistically significant( P<0.05). The adverse reaction group and the non-adverse reaction group had age, body weight, frequency of medication,comparison of indication selection, dosage,concentration, treatment course, the difference was statistically significant(P<0.05); Logistic regression analysis showed that unreasonable selection of dosage, concentration, frequency, and indications was the occurrence of adverse reactions independent risk factors( P<0.05).Conclusion In pediatric anti-infective therapy, azithromycin should be administered by oral administration, the dosage, concentration and indications should be strictly controlled, and the course of treatment should be shortened as much as possible to reduce the incidence of azithromycin adverse reactions.更多还原