【摘要】 目的比较米拉贝隆治疗膀胱过度活动症(OAB)的有效性和安全性,尤其是其对心血管系统的影响。方法计算机检索PubMed、Embase、Cochrane Liberary、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、万方数据库、维普数据库(VIP),纳入米拉贝隆治疗膀胱过度活动症的随机对照试验,根据纳入和排除标准选择文献并进行偏倚风险评价和数据提取,采用Revman5.3软件进行Meta分析。结果共检出335篇文献,最终纳入9个RCT,共14302例OAB患者。Meta分析结果显示,米拉贝隆治疗OAB的24h平均排尿次数、24h平均尿失禁次数、每晚平均夜尿次数、24h的平均尿急次数与索利那新比较,差异无统计学意义(P>0.05)。但索利那新每次排尿的平均排出量优于米拉贝隆(P=0.02),米拉贝隆发生高血压、QT间期延长、心律失常、心动过速与安慰剂比较,差异无统计学意义(P>0.05);米拉贝隆口干发生率低于索利那新,差异有统计学意义(P=0.0002)。结论米拉贝隆治疗OAB与索利那新疗效相当,但口干等不良反应发生率更低,并且不会增加心血管系统相关风险。因此,米拉贝隆具有良好的耐受性,是一种有效和安全的药物治疗方法。更多还原

【Abstract】 Objective This article aims to compare the effectiveness and safety of mirabegron in the treatment of overactive bladder(OAB), especially its impact on the cardiovascular system.Methods Computer search PubMed, EMbase, Cochrane Liberary, Chinese Journal Full-text Database(CNKI),Chinese Biomedical Literature Database(CBM), Wanfang Database, Vip Database(VIP), and included a randomized control of mirabegron for the treatment of overactive bladder in the experiment, literatures were selected according to the inclusion and exclusion criteria, and bias risk evaluation and data extraction were performed. Meta analysis was performed using Revman5.3 software.Results A total of 335 articles were detected, and finally9 RCTs were included, with a total of 14,302 patients with OAB.Meta analysis showed that the mean number of micturition per 24,the mean number of incontinence episodes per 24 h、the mean number of nocturia per night、and the urgency episodes per 24 h were not statistically significant(P>0.05).However, the volume voided per micturitionsolinacin was superior to mirabegron(P=0.02).Compared with placebo, the incidence of hypertension, QT prolongation, arrhythmia, tachycardia and placebo in mirabegron were not statistically significant( P> 0.05); the incidence of dry mouth of mirabegron was lower than solinaxin,the difference was statistically significant(P=0.0002).Conclusion Mirabegron is equivalent to solinaxin in the treatment of OAB, but the incidence of adverse reactions such as dry mouth is lower, and it does not increase the cardiovascular system-related risks. Therefore,mirabegron is well tolerated and is an effective and safe drug treatment method.更多还原