【摘要】 肝癌是世界范围内发病率和死亡率排名较高的恶性肿瘤之一,研究其发生发展的机制及有效防治方法具有重要意义。外泌体是一类由细胞分泌的细胞外囊泡,直径30～150 nm,表面携带特定分子,可以通过受体-配体结合或内吞作用传递信息至靶细胞从而发挥作用,是肿瘤微环境中重要的组成部分,其在肝癌的发生发展过程中扮演了重要的角色,有望作为肝癌的诊断和预后判断的理想肿瘤标志物。本文就外泌体的概述及其在肝癌中的作用作一综述,旨在为临床治疗该疾病提供参考。更多还原

【Abstract】 Liver cancer is one of the malignant tumors ranked high in morbidity and mortality worldwide. It is of great significance to study the mechanism of its occurrence and development and effective prevention methods. Exosomes are a type of extracellular vesicles secreted by cells, with a diameter of 30 to 150 nm, carrying specific molecules on the surface, which can play a role in transmitting information to target cells through receptor-ligand binding or endocytosis. An important part of the environment, which plays an important role in the occurrence and development of liver cancer, is expected to be an ideal tumor marker for the diagnosis and prognosis of liver cancer. This article reviews the overview of exosomes and their role in liver cancer, and aims to provide a reference for clinical treatment of the disease.更多还原