【摘要】 目的　分析呼吸道解脲支原体感染并发呼吸窘迫综合征(respiratory distress syndrome,RDS)患儿血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白介素-1β(interleukin-1β,IL-1β)、白介素-6(interleukin-6,IL-6)水平变化及其临床意义。方法选取2017年3月至2018年9月在襄阳市中心医院和湖北省妇幼保健院接受治疗的347例轻、中度RDS患儿为研究对象,将解脲支原体检测结果为阳性的82例患儿纳入观察组,其余265例患儿纳入对照组;检测两组患儿入院后血清TNF-α、IL-1β、IL-6水平,观察组患儿采用机械通气联合红霉素治疗,比较治疗前后患儿血清TNF-α、IL-1β、IL-6水平。结果观察组患儿TNF-α、IL-1β和IL-6水平均显著高于对照组(均P<0.01);观察组患儿各亚组血清TNF-α、IL-1β和IL-6水平均显著高于对照组(均P<0.01);随着观察组患儿RDS加重,以上炎性因子水平也呈逐渐升高的趋势,各组间比较差异均有统计学意义(均P<0.01);经机械通气联合红霉素治疗后,观察组患儿血清TNF-α、IL-1β和IL-6水平均较治疗前均显著降低(均P<0.01)。结论　TNF-α、IL-1β、IL-6水平与解脲支原体感染并发的RDS严重程度有关,机械通气联合红霉素治疗可以有效抑制患儿体内炎性因子水平。更多还原

【Abstract】 Objective To analyze serum tumor necrosis factor-α (TNF-α),interleukin-1β (IL-1β) and interleukin-6 (IL-6) level in children with respiratory distress syndrome (RDS) induced by Ureaplasma urealyticum (UU) infection and their clinical significance.Method 347 children with mild to moderate RDS treated in Xiangyang Central Hospital and Hubei Provincial Maternal and ChildHealth Hospital from March 2017 to September 2018 were selected as research objects.According to the results of UU test,82 children with UU positive RDS were taken as observation group,and 265 children with UU negative RDS were taken as control group.The levels of TNF-α,IL-1β and IL-6 in the two groups were detected after admission.Children in observation group were treated with mechanical ventilation and erythromycin,the levels of TNF-α,IL-1β and IL-6 were compared before and after treatment.Result The levels of TNF-α,IL-1β and IL-6 in observation group were significantly higher than those of control group (all P<0.01).The levels of TNF-α,IL-1β and IL-6 in the subgroups of children in observation group were significantly higher than those in control group (all P<0.01).With the exacerbation of RDS in the observation group,the level of the above inflammatory factors increased gradually,and the differences among the groups were statistically significant (all P<0.01).The levels of TNF-α,IL-1β and IL-6 in observation group were significantly lower than those before treatment (P<0.01).Conclusion The levels of TNF-α,IL-1β and IL-6 were related to the severity of RDS disease induced by UU infection.Mechanical ventilation and erythromycin treatment can effectively inhibit the levels of inflammatory factors mentioned above.更多还原