【摘要】 目的心房颤动与体内的炎性反应状态密切相关。新型冠状病毒SARS-CoV-2引起的新型冠状病毒肺炎(COVID-19)患者可快速进展为重症肺炎、急性呼吸窘迫综合征(ARDS)或多器官功能衰竭(MOF),甚至死亡,炎性因子风暴是病情恶化的主要机制之一。病原体入侵人体,激活机体的免疫系统,释放促炎因子,当机体免疫系统失去负反馈调节时,导致炎性因子大量释放,最终引起炎性因子风暴。SARS-CoV-2病毒与ACE2结合,使AngⅡ水平升高,加重炎性反应,这些均促进了心房电重构或结构重构,增加心房颤动的易感性。更多还原

【Abstract】 Atrial fibrillation is closely related to the state of inflammation response in the body. Coronavirus disease 2019(COVID-19) caused by novel coronavirus which named as sars-cov-2 can rapidly progress to severe pneumonia, acute respiratory distress syndrome(ARDS) or multiple organ failure(MOF), and even death, cytokine storm is one of the main mechanisms for disease progression. The pathogen invades the human body, activates the body’s immune system, and releases pro-inflammatory factors.When the body’s immune system loses the negative feedback regulation, it leads to the release of a large number of inflammatory cytokines, and finally causes a cytokine storm. SARS-CoV-2 is combined with ACE2, makes the level of AngⅡ goes up, aggravating the inflammatory response, which promoted the atrial electrical or structure remodeling,increase the susceptibility of atrial fibrillation.更多还原