【摘要】 目的观察射血分数保留的心力衰竭(HF-PEF)患者血清中基质金属蛋白酶-2(MMP-2)、MMP-9及半乳糖凝集素-3(Gal-3)的浓度变化及其临床意义。方法选取2016年7月—2017年6月新疆医科大学第五附属医院心血管内科诊治的HF-PEF患者88例作为HF-PEF组,非心力衰竭患者35例为NHF组,均采用ELISA法测定血清MMP-2、MMP-9及Gal-3的浓度,超声测定左房直径(LA)、左室舒张末期内径(LVEDD)及左室射血分数(LVEF),并分析其相关性。结果 HF-PEF组患者血清MMP-2、MMP-9及Gal-3浓度明显高于NHF组(t/P=12.952/0.000、 17.618/0.000、 14.801/0.000),并随着心功能分级升高而显著增加(F/P=78.72/0.000、 127.531/0.000、 86.418/0.000);HF-PEF组LAD水平大于NHF组,LVEF水平低于NHF组(P均<0.01),而2组LVEDD水平比较差异无统计学意义(P>0.05)。血清MMP-2、MMP-9和Gal-3浓度与LAD、LVEDD呈正相关(LAD:r/P=0.716/0.000、 0.712/0.000、 0.661/0.000;LVEDD:r/P=0.267/0.012、 0.325/0.002、 0.280/0.008),与LVEF呈负相关(r/P=-0.357/0.001、-0.547/0.000、-0.451/0.000)。结论检测血清中MMP-2、MMP-9及Gal-3浓度有助于HF-PEF患者病情早期诊断及其疾病严重程度的判断。更多还原

【Abstract】 Objective To observe the changes of serum matrix metalloproteinase-2(MMP-2), MMP-9 and galactose agglutinin-3(Gal-3) in patients with heart failure(HF-PEF) with preserved ejection fraction and its clinical significance. Methods From July 2016 to June 2017, 88 HF-PEF patients were selected as HF-PEF group and 35 non heart failure patients as NHF group The concentrations of MMP-2, MMP-9 and Gal-3 in serum were measured by ELISA, the left atrial diameter(LA), left ventricular end diastolic diameter(LVEDD) and left ventricular ejection fraction(LVEF) were measured by ultrasound, and the correlation was analyzed. Results The concentrations of MMP-2, MMP-9 and Gal-3 in HF-PEF group were significantly higher than those in NHF group(t/P=12.952/0.000, 17.618/0.000, 14.801/0.000), and increased with the increase of cardiac function grade(F/P=78.72/0.000, 127.531/0.000, 86.418/0.000). The LA level of HF-PEF group was higher than that of NHF group, while the LVEF level of HF-PEF group was lower than that of NHF group(P<0.01). The concentrations of MMP-2, MMP-9 and Gal-3 were positively correlated with La and LVEDD(LAD: r/P=0.716/0.000, 0.712/0.000, 0.661/0.000; LVEDD: r/P=0.267/0.012, 0.325/0.002, 0.280/0.008), and negatively correlated with LVEF(r/P=-0.357/0.001,-0.547/0.000,-0.451/0.000). Conclusion The detection of MMP-2, MMP-9 and Gal-3 in serum is helpful for the early diagnosis of HF-PEF and the judgment of disease severity.更多还原