【摘要】 目的:探讨维持性血液透析（maintenance hemodialysis,MHD）患者颈动脉粥样硬化程度与血清25-羟维生素D₃水平的相关性。方法:选取2017年7-12月笔者所在医院血液透析室行MHD患者82例,经超声检测颈动脉内膜中膜厚度（intima-media thickness,IMT）,根据颈动脉IMT将患者分为颈动脉正常组（30例）、颈动脉内膜增厚组（31例）和颈动脉斑块组（21例）。比较三组血清25-羟维生素D₃水平。分析颈动脉粥样硬化程度与血清25-羟维生素D₃水平的相关性。结果:颈动脉斑块组、颈动脉内膜增厚组血清25-羟维生素D₃水平均低于颈动脉正常组,差异有统计学意义（P<0.05）,且颈动脉斑块组低于颈动脉内膜增厚组,差异有统计学意义（P<0.05）。Spearman相关性分析显示,颈动脉粥样硬化程度与血清25-羟维生素D₃水平呈负相关（r=-0.647,P<0.05）。结论:颈动脉粥样硬化程度与血清25-羟维生素D₃水平呈负相关,低血清25-羟维生素D₃水平的MHD患者具有颈动脉粥样硬化程度加重的危险,血清25-羟维生素D₃水平的检测有助于预测颈动脉粥样硬化程度,提高血清25-羟维生素D₃水平可一定程度保护颈动脉IMT增厚。更多还原

【Abstract】 Objective:To explore the correlation between carotid atherosclerosis degree and serum 25-hydroxyvitamin D₃ level in maintenance hemodialysis patients （MHD）.Method:Eighty-two patients with MHD in the hemodialysis room of our hospital from July to December 2017 were selected.Intima-media thickness （IMT） of carotid was measured by ultrasound.According to carotid IMT,the patients were divided into the carotid normal group （30 cases）,the carotid intima thickening group （31 cases） and the carotid plaque group （21 cases）.The serum 25-hydroxyvitamin D₃ level were compared among the three groups.The correlation between the carotid atherosclerosis degree and serum 25-hydroxyvitamin D₃ level was analyzed.Result:The serum 25-hydroxyvitamin D₃ level in the carotid plaque group and the carotid intima thickening group were lower than those in the carotid normal group,the differences were statistically significant （P<0.05）,and the carotid plaque group was lower than the carotid intima thickening group,the difference was statistically significant （P<0.05）.Spearman correlation analysis showed that the carotid atherosclerosis degree was negatively correlated with serum 25-hydroxyvitamin D₃ level （r=-0.647,P<0.05）.Conclusion:The carotid atherosclerosis degree is negatively correlated with serum 25-hydroxyvitamin D₃ level,MHD patients with low serum 25-hydroxyvitamin D₃ level are at risk for increased carotid atherosclerosis.The detection of serum 25-hydroxyvitamin D₃ level is helpful to predict the degree of carotid atherosclerosis,and the increase of serum 25-hydroxyvitamin D₃ level can protect the carotid IMT thickening to some extent.更多还原