【摘要】 目的:探索BOLD及DKI磁共振功能成像技术在认知功能损害脑瘫儿的应用。方法:选取伴有认知功能障碍脑瘫患儿(CP组)52例及正常小儿(CG组)50例,使用PhilipsIngenia3.0T多模态磁共振功能成像技术,在静息状态下行高分辨T1WI、BOLD及可行性DKI扫描,采集统计及分析MR功能数据。结果:CP组与CG组比较:①BOLD成像ALFF值:左丘脑、左壳核、左楔前回及右角回、右扣带回后部的ALFF值升高(P <0.05)。②ReHo值:左额上回、左岛叶皮质、左枕回、右额中回、右颞上回Reho值降低(P<0.05);左额叶白质、左顶下小叶、左丘脑、右额叶白质、右扣带回Reho值升高(P <0.05)。③DKI成像MK值:CP组双额叶、双顶叶、双枕叶MK值均低于CG组(P <0.05)。结论:RS-fMRI为无创性敏感研究认知功能障碍脑瘫儿脑灰白质功能、微观结构及病损的重要影像学方法。更多还原

【Abstract】 Purpose: To investigate the application of BOLD and DKI in children with cerebral palsy with cognitive impairment.Methods:Fifty-two cases of cerebral palsy children with cognitive impairment and 50 cases of normal children were enrolled.Multimode functional magnetic resonance imaging including high-resolution T1 WI, resting state BOLD fMRI and DKI were undergone on a Philips Ingenia 3.0 T scanner.All the MR function data were collected and analyzed.Results: Compared with CG group, ALFF values of left thalamus, left putamen, left anterior wedge gyrus, right angular gyrus and posterior right cingulate gyrus were increased in CP group(P<0.05). Compared with CG group, ReHo values of left superior frontal gyrus, left insular cortex, left occipital gyrus, right middle frontal gyrus and right superior temporal gyrus were decreased in CP group(P< 0.05);Compared with CG group,ReHo values of left frontal white matter, left inferior parietal lobule, left thalamus, right frontal white matter and right cingulate gyrus were increased in CP group(P< 0.05). MK values of bilateral frontal lobe, bilateral parietal lobe and bilateral occipital lobe in CP group were lower than those in CG group(P< 0.05).Conclusion:Rs-fMRI is an important imaging method for non-invasive study of the function, microstructure and lesion of gray matter in cerebral palsy children with cognitive dysfunction.更多还原