【摘要】 目的观察电子支气管镜支气管肺泡灌洗(BAL)治疗重症肺部感染患者的临床疗效及对炎症水平的影响。方法选取2017年1月—2018年10月我院收治的重症肺部感染患者122例为研究对象,随机分成对照组(61例)与观察组(61例),其中对照组患者实施常规抗感染治疗,而观察组患者采取电子支气管镜进行BAL。对比两组患者治疗前后炎症指标水平、血气指标、肺功能指标及细菌清除率及临床疗效。结果两组患者治疗前各项炎症指标水平差异无统计学意义(P>0.05);治疗后两组患者的炎性指标水平明显降低,而观察组患者各指标水平明显低于对照组(P <0.001)。治疗前两组患者的血气指标水平相比,差异无统计学意义(P>0.05);经治疗后两组患者的血气指标水平明显改善,其中观察组患者血气指标水平明显优于对照组,差异具有统计学意义(P <0.001)。治疗前两组患者的肺功能指标水平相比,差异无统计学意义(P>0.05);经治疗后两组患者的肺功能指标水平明显改善,其中观察组患者肺功能指标水平明显优于对照组,差异具有统计学意义(P <0.001)。观察组患者细菌清除率为93.44%,明显高于对照组的45.90%;且观察组患者临床治疗总有效率为95.08%,明显高于对照组的65.57%,差异具有统计学意义(P <0.001)。结论在重症肺部感染患者治疗中,采取电子支气管镜进行BAL治疗,相对于常规抗感染治疗,可明显减轻患者的炎性指标水平,改善血气指标与肺功能水平,提升细菌清除率与临床治疗效果。更多还原

【Abstract】 Objective To observe the clinical effect of bronchoalveolar lavage(BAL)with electronic bronchoscope in the treatment of patients with severe pulmonary infection and its influence on the level of inflammation. Methods A total of 122 patients with severe pulmonary infection admitted to our hospital from January2017 to October 2018 were randomly divided into the control group(61 cases)and the observation group(61 cases).Patients in the control group received conventional anti-infection treatment,while patients in the observation group received BAL treatment with electronic bronchoscopy.The inflammatory index levels,blood gas indexes,lung function indexes before and after treatment,bacterial clearance rates and clinical efficacy of the two groups were compared. Results There was no statistically significant difference between the two groups in the levels of inflammatory indexes before treatment(P >0.05).After treatment,the inflammatory index levels of both groups were significantly decreased,while every index level of the observation group was significantly lower than that of the control group(P <0.001).There was no significant difference in the blood gas index levels between the two groups before treatment(P >0.05).After treatment,the blood gas index levels of both groups were significantly improved,and the blood gas index level of the observation group was significantly higher than that of the control group,so the difference was statistically significant(P <0.001).The comparison of pulmonary function indexes between the two groups showed no significant difference before treatment(P >0.05).After treatment,their pulmonary function indexes were all significantly improved,but their pulmonary function index of the observation group was significantly better than that of the control group,showing significant difference(P <0.001).The bacterial clearance rate of the observation group was 93.44%,which was significantly higher than that of the control group(45.90%).Moreover,the total effective rate of clinical treatment in the observation group was 95.08%,which was significantly higher than that in the control group(65.57%),so the difference was statistically significant(P <0.001). Conclusion In the treatment of patients with severe pulmonary infection,compared with conventional anti-infection treatment,the BAL treatment with electronic bronchoscope can significantly reduce the inflammatory index level of patients,improve the blood gas index and lung function level as well as promote the bacterial clearance rate and clinical treatment effect.更多还原