【摘要】 目的探讨小剂量氨磺必利联合草酸艾司西酞普兰治疗艾滋病病毒感染者(PLWH)伴发首发抑郁的疗效及安全性。方法按照简单随机化方法将80例AIDS伴首发抑郁患者分为研究组(40例)与对照组(40例),两组患者均应用草酸艾司西酞普兰5～10 mg抗抑郁治疗,每天1次;研究组在此基础上加用小剂量氨磺必利治疗,开始时服用50 mg/d,根据病情变化,可以调整到100～200 mg/d。两组疗程均为6周。在治疗前及治疗1、2、4、6周末,使用汉密尔顿抑郁量表(HAMD)评定疗效,以HAMD减分率≥50%为有效。使用症状量表(TESS)评定治疗中出现的不良反应。结果 6周治疗完成后,两组HAMD得分均随治疗时间明显下降,时间效应显著(F=12.16,P<0.001),组别效应显著(F=35.31,P<0.001);研究组治疗6周后有效率(87.18%)明显高于对照组(65.00%),差异有统计学意义(P<0.05);两组间不良反应发生率差异无统计学意义(χ~2=0.111,P>0.05)。结论小剂量氨磺必利联合草酸艾司西酞普兰治疗PLWH伴首发抑郁患者疗效优于单用草酸艾司西酞普兰,不良反应与单用草酸艾司西酞普兰相似。更多还原

【Abstract】 Objective To investigate effect and safety of small dose of amisulpride combined with Escitalopram oxalate in treatment of people living with HIV/AIDS(PLWH)complicated with first depression. Methods Eighty AIDS patients complicated with first depression were enrolled. According to simple randomization method, the patients were divided into a study group(n=40) and a control group(n=40). Both groups were treated with Escitalopram oxalate(5～10 mg, once daily)and on the basis of this treatment the study group was added with small dose of amisulpride, the initial dose of oral amisulpride was 50 mg/d, but the dose could be adjusted to 100～200 mg/d depending on the changes of disease. Both of the treatment course of the two groups was six weeks. The efficacy were assessed with Hamilton depression rating scale(HAMD) before treatment and at the end of 1-, 2-, 4-, and 6-week treatment, the HAMD reduction rate ≥50% was regarded as therapeutic efficacy. The adverse effects occurred in treatment were assessed by using The Treatment Emergent Symptom Scale(TESS). Results After 6 weeks of treatment, the HAMD scores significantly decreased in the two groups as treatment time passed, there was significant time effect(F=12.16, P<0.001) and group effect(F=35.31, P<0.001). After 6 weeks of treatment, the study group showed more improvement rate(87.18%) than the control group(65.00%), the difference was significant(P<0.05). The difference of adverse reactions rate between the two groups was not significant(χ~2=0.111,P>0.05). Conclusion Small dose of amisulpride combined with Escitalopram oxalate is more effective than single Escitalopram oxalate for PLWH complicated with first depression, and the adverse reactions are similar to single use of Escitalopram oxalate.更多还原