【摘要】 目的旨在构建药物性肝损伤(DILI)风险评估指标体系,以降低DILI的发生率。方法通过文献查阅,确定风险指标条目池,采用德尔菲法最终确定DILI风险指标评估体系。结果两轮问卷的回收率为100%,专家权威系数为0.82,两轮协调系数分别为0.40和0.63;形成了包括药物因素、宿主因素、行为因素、环境因素和认知因素五个方面,共23个条目的DILI风险评估指标体系。结论应用德尔菲法初步构建的DILI风险评估指标体系具有一定的科学性、实用性,但仍需进一步验证。更多还原

【Abstract】 【Objective】To construct a risk assessment index system for drug-induced liver injury to reduce the incidence of drug-induced liver injury(DILI).【Methods】Through the literature review, the pool of risk indicators was determined, and the Delphi method was used to determine the risk assessment index of drug-induced liver injury.【Results】The recovery rate of the two rounds of questionnaires was 100%, the expert authority coefficient was 0.82, and the two rounds of coordination coefficients were 0.40 and 0.63, respectively. Five aspects including drug factors, environmental factors, host factors, behavioral factors and cognitive factors were formed. A 23-item DILI risk assessment indicator system was constructed. 【Conclusion】 The risk assessment index system for drug-induced liver injury, which was initially constructed by Delphi method, is of scientificity and practicability, but it still needs further verification.更多还原