【摘要】 目的探讨血液系统恶性肿瘤(HMs)化疗后发生不良事件的危险因素。方法回顾性分析200例行化疗的HMs患者的资料,对其化疗后不良事件发生的影响因素进行单因素分析,并采用Logistic回归分析法进行危险因素分析。结果体质量指数(BMI)≥25 kg/m~2、急性白血病、高强度化疗、有心律失常病史、高血压、脑血管病、凝血功能异常的HMs患者不良事件发生率分别高于BMI <25 kg/m~2、非急性白血病、低/中强度化疗、无心律失常病史、无高血压、无脑血管病、非凝血功能异常的HMs患者,差异均有统计学意义(P <0. 05或P <0. 01); Logistic回归分析显示,BMI≥25 kg/m~2、急性白血病、高强度化疗及凝血功能异常为HMs化疗后不良事件发生的独立危险因素(P <0. 01)。结论 HMs患者化疗后不良事件发生的独立危险因素主要为肥胖、急性白血病、高强度化疗与合并凝血功能异常,临床可根据这些因素评估患者不良事件发生风险。更多还原

【Abstract】 Objective To analyze the risk factors of occurrence of adverse events in hematological malignancies( HMs) after chemotherapy. Methods The data of 200 HMs patients who underwent chemotherapy in the hospital were retrospectively analyzed. Univariate analysis and Logistic regression analysis were performed on the factors affecting adverse events after chemotherapy,and its risk factors,respectively. Results The incidences of adverse events in HMs patients with body mass index( BMI) ≥ 25 kg/m~2,acute leukemia,high-intensity chemotherapy,arrhythmia history,hypertension,cerebrovascular disease and abnormal blood coagulation function were significantly higher than those with BMI < 25 kg/m~2,non-acute leukemia,low/medium-intensity chemotherapy,arrhythmia-free history,normal blood pressure and coagulation function,and in those without cerebrovascular disease( P < 0. 05 or P < 0. 01). Logistic regression analysis showed that BMI ≥25 kg/m~2,acute leukemia,high-intensity chemotherapy and coagulation function abnormalities were independent risk factors for occurrence of adverse events for HMs after chemotherapy( P < 0. 05). Conclusion The independent risk factors for occurrence of adverse events after chemotherapy in HMs patients mainly include obesity,acute leukemia,high-intensity chemotherapy and coagulation function abnormalities,the occurrence risk of adverse events can be assessed according to these factors in clinic.更多还原