【摘要】 嗅觉与人类生活息息相关,可以对危险环境提前预警,有助于协助食物的摄入和选择,双向控制人体能量稳态,对人类感觉及荷尔蒙发出的信号做出一系列反应^[1]。嗅觉评级也可以用来测定种族歧视及偏见^[2],因此嗅觉障碍对于病人来讲具有相当的个人与现实意义。而嗅神经上皮有再生能力,相对持续性的神经再生可以在嗅上皮基底部完成,基于此原理,让许多医务工作者和科学家在相关嗅觉障碍疾病的治疗上看到曙光。早期研究发现生长因子在嗅觉神经发生中起关键作用,如神经生长因子（NGF）,是神经营养因子家族中首次发现的成员,可以刺激嗅神经元再生,对选定的外周神经元群体分化起作用,促进和调节周围神经系统神经元存活^[3],在体外可以保护嗅细胞和轴突免受损伤^[4],但具体机制不清,本文针对神经生长因子（NGF）在嗅觉系统的作用及相互关系进行综述。更多还原

【Abstract】 Objective Olfaction is closely related to human life. It can provide early warning of dangerous environment, help to assist food intake and selection, and signal the two-way control of energy homeostasis on sensory and hormonal responses. Olfactory ratings can also be used to determine racial discrimination and prejudice, so olfactory disorders have considerable personal and practical implications for patients. While the olfactory epithelium has regenerative capacity, relatively continuous neurological regeneration can be done at the base of the olfactory epithelium. Based on this principle, many medical workers and scientists have seen the dawn of treatment of related olfactory disorders. Early studies have found that growth factors play a key role in olfactory neurogenesis, such as nerve growth factor(NGF), a member of the first discovered neurotrophic family that stimulates olfactory neuron regeneration, with unclear mechanisms for selected peripherals. Neuronal population differentiation plays a role in promoting and regulating neuronal survival in peripheral nervous systems, protecting olfactory cells and axons from damage in vitro. This article reviews the role of NGF in olfactory system and its relationship with olfactory system.更多还原