【摘要】 目的探讨普萘洛尔治疗婴幼儿血管瘤的临床效果。方法选取2016年3月～2018年3月医院收治的56例婴幼儿血管瘤病例,给予普萘洛尔1.5～2 mg/(kg·d),分2次进食后服用,治疗期间密切监测患儿的不良反应发生情况,观察并记录血管瘤质地、颜色、大小的变化,采用Achauer 4级评分法进行疗效评价。结果患儿服用普萘洛尔24 h后,大部分瘤体的质地、颜色、大小均有不同程度的改善;6个月后疗效评定的总有效率为83.93%,其中头颈部、四肢、躯干血管瘤的总有效率分别为88.57%、77.78%、75.00%。治疗期间未发生严重不良反应,仅1例出现轻度吐奶,2例出现腹泻,不良反应发生率为5.36%,均未给予特殊处理,症状自行缓解。结论普萘洛尔治疗婴幼儿血管瘤的疗效确切,不良反应轻微,安全性好。更多还原

【Abstract】 Objective To explore the efficacy of propranolol in treatment of infantile hemangioma. Methods A total of 56 cases of infantile hemangioma admitted to our hospital from March 2016 to March 2018 were selected and administrated with propranolol after meal, b.i.d., 1.5-2 mg/kg in total. During the treatment, close monitoring of adverse reactions was conducted for the children, and the changes of hemangioma texture, color and volume were observed and recorded. Achauer’s 4-point scale was applied to evaluate the efficacy. Results After administration of propranolol for 24 hours, the children had varying degrees of improvement in the texture,color and volume of most hemangiomas. After six months, the total effective rate of efficacy was evaluated as 83.93%, among which the total effective rates of efficacy for hemangiomas in head and neck, limbs and trunk were 88.57%, 77.78% and 75.00%,respectively. During the treatment, no serious adverse reactions occurred, with only one case of mild regurgitation of milk and two cases of diarrhea. The incidence of adverse reactions was 5.36%. No special treatment was given and the symptoms were relieved spontaneously. Conclusion Propranolol is safe and effective in treatment of infantile hemangioma, with mild adverse reactions.更多还原