【摘要】 目的分析济南地区无偿献血人群梅毒感染状况,为制定无偿献血招募策略提供依据。方法使用2种酶联免疫试剂筛查献血者梅毒抗体,筛查反应性样本用梅毒螺旋体抗体检测试剂(TPPA)确证,根据献血年份、性别和年龄、文化程度、献血次数和职业分别比较献血人群的梅毒感染状况。结果 2015至2018年济南地区有278 003人进行过一次或者重复献血,梅毒确证阳性506人(0.18%),感染率呈逐年上升趋势,不同年份之间感染率比较,差异无统计学意义(P>0.05);男性阳性率(0.19%)高于女性(0.17%),但差异无统计学意义(P>0.05);18岁～24岁年龄组阳性率明显低于其他年龄组,差异具有统计学意义(P<0.01);初中及以下学历阳性率明显高于高中学历以上群体,差异具有统计学意义(P<0.01);初次献血者阳性率明显高于重复献血者,差异具有统计学意义(P<0.01)。结论济南地区献血者中梅毒抗体阳性率呈逐年上升趋势,不同年龄、不同文化程度及不同献血次数梅毒感染率存在差异,查体医师应加强对高危人群征询的责任,确保临床用血安全。更多还原

【Abstract】 Objective To provide the basis for recruiting strategy adjustment by analyzing the prevalence of syphilis infections among blood donors in Ji′nan. Methods Two kinds of enzyme-linked immunosorbent reagents were used to screen syphilis antibodies in blood donors, and the reactive samples were confirmed with treponema pallidum antibody detection reagent(TPPA). The syphilis infection status of the blood donors was compared according to the year of blood donation, gender and age, education level, frequency of blood donations, and occupation. Results Between 2015 and 2018, 278 003 people in Ji′nan had once or repeatedly donated blood, and 506 people were positive for syphilis(0.18%). The infection rate was increasing year by year, with no statistically significant differences in infection rate between different years(P > 0.05). Male positive rate(0.19%) was higher than female(0.17%), but the difference was not statistically significant(P > 0.05). The positive rate of 18-24 age group was significantly lower than other age groups, with statistically significant differences(P <0.01). The positive rate in donors with junior high school and below was significantly higher than that of high school graduates, with statistically significant differences(P<0.01). The positive rate of the first blood donor was significantly higher than that of the repeated blood donors, with statistically significant differences(P<0.01). Conclusions The positive rate of syphilis antibody in blood donors in Jinan is increasing year by year. There are differences in syphilis infection rates among donors with different ages, different educational levels and different blood donation frequency, so consultation with high-risk groups should be strengthened to ensure the safety of clinical blood.更多还原