【摘要】 目的对深圳市宝安区梅毒血清固定的妊娠期孕妇的状况进行筛查及了解规范性治疗对妊娠结局和新生儿的影响。方法选取2015年1月至2017年12月深圳市宝安区医疗单位进行免费梅毒保健筛查的妊娠期孕妇作为观察对象。对妊娠期梅毒患者的数量及梅毒血清固定的人数比例进行分析。梅毒血清固定孕妇,根据第一疗程、第二疗程同时驱梅用药患者作为治疗组,而两疗程没有同时进行药物治疗或两疗程均没有驱梅用药的患者作为未治疗组,选取同期正常孕妇作为对照组,观察规范性治疗对妊娠结局和新生儿影响。结果 2015年1月至2017年12月深圳市宝安区梅毒筛查中,3年的梅毒确诊分别为204例、154例和195例;血清固定孕妇占比分别为5.39%、9.74%和3.07%;在血清固定组患者中不良结局妊娠上三组之间差异无统计学意义(P>0.05);梅毒血清固定患者中治疗组新生儿血清梅毒阳性率和不良事件发生率均显著低于未治疗组,差异具有统计学意义(均P<0.05)。结论本次研究结果显示,在梅毒血清固定患者中采取药物治疗对于提高新生儿的存活率、降低新生儿血清感染率和不良疾病发生率上均具有较好帮助,值得在梅毒血清型固定妊娠妇女中推荐应用。更多还原

【Abstract】 Objective To describe the situation of pregnant women with syphilis serum in Baoan District of Shenzhen, in order to understand the influence of standardized treatment on the pregnancy outcome and newborns. Methods Pregnant women received free syphilis health screening in medical institutions in Bao′an District from January 2015 to December 2017 were selected as the observation objects, and the number of syphilis patients during pregnancy and the proportion of syphilis sero-resistance were analyzed. Those received drug treatment in the first and second course of treatment at the same time were selected as the treated group, otherwise as the untreated group, and the normal pregnant women in the same period were selected as control group. The effect of standardized treatment on pregnancy outcome and neonates were observed. Results There were 204 cases, 154 cases and 195 cases of syphilis diagnosed during the screening of syphilis in Baoan District of Shenzhen City from 2015 to 2017, and the proportion of pregnant women with syphilis sero-resistance was 5.39%, 9.74% and 3.07% respectively. There was no statistically significant difference in the incidence of adverse outcomes between the three groups(P>0.05). The positive rate of serum syphilis and incidence of adverse events in the treated group were significantly lower than those in the untreated group, with statistically significant differences(all P <0.05). Conclusions Medication in patients with syphilis sero-resistance is conductive to improving the survival rate of newborns, reducing the serum infection rate of newborns and the incidence of adverse diseases, thusly worth recommending in clinical.更多还原