【摘要】 目的使用光学相干断层扫描血管成像（optical coherence tomography angiography,OCTA）观察正常眼压性青光眼（normal tension glaucoma,NTG）黄斑区视网膜厚度（macular retinal thickness,MRT）和黄斑区血管密度（macular vessel density,MVD）改变,并探讨其与视野平均缺损的相关性。方法选取NTG患者20例（40眼）为NTG组,健康20人（40眼）为对照组。利用OCTA检测2组MRT和MVD,对比NTG组与对照组间的差异性,并检验NTG组黄斑区检测指标与视野平均缺损的相关性。结果 NTG组与对照组受检者MRT、MVD在黄斑区中心凹、旁中心凹、上方及下方比较,差异均有统计学意义(F_中心凹MRT=26.923、F_{旁中心凹MRT}=38.176、F_上方MRT=22.324、F_下方MRT=39.936、F_中心凹MVD=36.154、F_{旁中心凹MVD}=45.573、F_上方MVD=29.345、F_下方MVD=30.267;均为P<0.01),而在颞侧和鼻侧两个象限MRT、MVD差异均无统计学意义(F_颞侧MRT=2.614、F_鼻侧MRT=2.497、F_颞侧MVD=2.134、F_鼻侧MVD=1.937;均为P>0.05);NTG组的黄斑中心凹、旁中心凹、上方及下方的MRT、MVD与视野平均缺损均具有相关性（均为P<0.01）。结论利用OCTA技术可以有效地反映NTG黄斑区形态学改变特征,且这种改变与视野平均缺损相关,从而可在疾病的早期提供无创影像学诊断支持,为尽早干预治疗提供帮助。更多还原

【Abstract】 Objective To use optical coherence tomography angiography（OCTA） to observe the changes of macular retinal thickness（MRT） and macular vessel density（MVD） in the macular area of normal-tension glaucoma,and to explore its relevance to visual field.Methods Twenty NTG patients（40 eyes） were selected as the TNG group, and 20 patients（40 eyes） of normal persons as the control group. OCTA was used to obtain the MRT and MVD in the macular area. The difference between the NTG group and the control group was statistically analyzed and the correlation between the macular area detection index and the visual field defect in the NTG group was tested.Results We obtained the MRT and MVD in the macular area of the subject by OCTA, and found that there were statistically significant difference in the MRT and MVD in the macular area at the four directions of fovea, paracentral fovea, top and bottom between the NTG group and the control group(F_{fovea MRT}=26.923,F_{paracentral fovea MRT}=38.176,F_{top MRT}=22.324,F_{bottom MRT}=39.936,F_{fovea MVD}=36.154,F_{paracentral MVD}=45.573,F_{top MVD}=29.345,F_{bottom MVD}=30.267;All P<0.01), but there was no statistical difference between two groups in temporal and nasal sides(F_{temporal MRT}=2.614,F_{nasal MRT}=2.497,F_{temporal MVD}=2.134,F_{nasal MVD}=1.937;All P>0.05). The fovea, paracentral fovea, top and bottom of the NTG group were correlated with the mean deviation of visual field（all P<0.01）.Conclusion The use of OCTA technology can effectively reflect the characteristics of NTG macular morphological changes, and this change is related to visual field defect, which can provide non-invasive imaging diagnosis support in the early stage of the disease and provide help for early intervention treatment.更多还原