【摘要】 目的探讨不同剂量金振口服液联合阿奇霉素治疗儿童支原体肺炎的临床疗效。方法回顾性分析成都市第一人民医院儿科和南充市中心医院儿科2016年1月～2018年4月收治的75例支原体肺炎住院患儿的临床资料,按金振口服液药量分为加倍剂量组、常规剂量组和对照组3组,每组25例。3组均给予阿奇霉素作为基础治疗,加倍剂量组在基础治疗上给予金振口服液加倍剂量:2～3岁,20 mL/次,一日2次;4～7岁,20 mL/次,一日3次;8～12岁,30 mL/次,一日3次;常规剂量组金振口服液予以常规治疗剂量:2～3岁,10 mL/次,一日2次;4～7岁,10 mL/次,一日3次;8～13岁,15 mL/次,一日3次;对照组各年龄段均未口服金振口服液。比较3组患儿临床治疗总有效率、临床痊愈时间、完全退热时间、咳嗽或咯痰消失时间、肺部啰音消失时间、胸片炎症吸收时间及并发症发生率。结果加倍剂量组及常规剂量组总有效率均高于对照组(P<0.05);加倍剂量组、常规剂量组咳嗽或咯痰缓解时间、肺部啰音消失时间均较对照组时间短(P<0.05);3组患儿退热时间组间比较,差异均无统计学意义(P>0.05)(退热无效者均为并发中枢感染患儿);加倍剂量组和常规剂量组肺部胸片炎症吸收时间均短于对照组(P<0.05);患儿不良反应比较,加倍剂量组腹泻发生率显著高于常规剂量组与对照组(P<0.05)。加倍剂量组未出现复发,常规剂量组及对照组均复发1例。结论金振口服液联合阿奇霉素治疗儿童支原体感染肺炎可缩短病程,改善病情。但加大金振口服液剂量对治疗效果无明显差异,反而对胃肠道功能有一定影响,值得临床医师借鉴。更多还原

【Abstract】 Objective To investigate the effect of different doses of Jinzhen oral liquid combined with azithromycin in the treatment of mycoplasma pneumonia in children. Methods 75 hospitalized children were selected from the pediatrics department of Chengdu First People′s Hospital and Nanchong Central Hospital from 2016 to 2018 and divided into double dose group, routine dose group and control group. Azithromycin was given to all three groups as the basic treatment, and the double dose group was given double dose of Jinzhen oral liquid on the basis of the basic treatment, every 20 ml, 2 times a day for 2～3 years old children; every 20 ml, 3 times a day for 4～7 years old children; every 30 ml, 3 times a day for 4～7 years old children. Conventional dose is the half of the double dose. The control group did not take oral Jinzhen oral liquid at all.The total clinical treatment efficiency, clinical recovery time, time of complete antipyretic, time of disappearance of cough or cough phlegm, time of disappearance of rafter sound in lungs, time of absorption of chest film inflammation and incidence of complications were compared in the three groups. Results The total effective rate of the double dose group was higher than that of the conventional dose group and the control group(P<0.05). The total effective rate of the conventional dose group was higher than that of the control group, and the difference was statistically significant(P<0.05). The remission time of cough or cough phlegm and the disappearance time of rale in lung in the double dose group were shorter than those in the conventional dose group and the control group(P<0.05). Compared with the control group, the time of relieving cough or phlegm and the time of disappearance of rale in lung were shorter in the conventional dose group, with statistically significant differences(P<0.05). There was no statistically significant difference in the time of antipyretic among the three groups(P>0.05)(all the children with concurrent central infection were those with no antipyretic effect). The inflammatory absorption time of chest film in the double dose group(7.5±2.5 days) was shorter than that in the conventional dose group(8.0±3.0 days) and the control group(10.5±4.5 days)(P<0.05). The inflammatory absorption time of chest radiograph in the conventional dose group was shorter than that in the control group(P<0.05). There was no statistically significant difference in the incidence of complications among the three groups(P>0.05). There was no recurrence in the double dose group, and there was 1 recurrence in both the conventional dose group and the control group. There was no statistically significant difference in the three groups(P>0.05).Conclusion Jinzhen oral liquid combined with azithromycin can shorten the course of mycoplasma infection and pneumonia in children. It is worthy of clinical application.更多还原