【摘要】 目的研究多模态磁共振功能成像对粤东地区前列腺癌的诊断价值。方法选取2019年医院收治的前列腺癌患者46例纳入研究对象,设为前列腺癌组,选取同期体检健康的46名志愿者,设为对照组。所有患者及志愿者均接受行动态对比增强(DCE-MRI)、扩散加权磁共振成像(DW1)、磁共振氢质子波普(MRS)扫描,探讨DCE-MRI、DW1、MRS扫描在前列腺癌中的诊断价值。结果 46例前列腺癌患者发现癌灶52个,其中42个T2W1低信号结节,3个等信号结节,3个高信号结节,4个高低混杂信号结节;病灶位置分别在外周带(29个)、中央带(23个),其中癌灶突出包膜30例、侵及精囊腺14例、骨转移8例; 46名志愿者结节均位于中央带,T1W1信号略低,26个T2W1低信号结节,17个等信号结节,8个低信号。两组DCE-MRI扫描TIC分型对比差异有统计学意义(P <0.05);前列腺癌组ADC值显著低于对照组,且前列腺癌组(Cre+Cho)/Cit比值显著高于对照组,差异有统计学意义(P <0.05)。结论粤东地区前列腺癌患者DCE-MRI扫描TIC分型多为Ⅱ、Ⅲ型,诊断难度较大,而DW1、MRS扫描中前列腺癌患者ADC值显著降低、(Cre+Cho)/Cit值显著升高,因此临床诊断中建议行DCE-MRI、DW1、MRS联合扫描,减少漏诊、误诊。更多还原

【Abstract】 Objective To study the diagnostic value of multimodal functional magnetic resonance imaging( MRI) for prostate cancer in eastern Guangdong province. Methods A total of 46 patients with prostate cancer were included as the prostate cancer group,and 46 healthy volunteers enrolled for physical examination during the same period were selected as the control group. All the patients and volunteers received dynamic contrast-enhanced imaging( dce-mri),diffusion-weighted magnetic resonance imaging( DW1),and magnetic resonance hydrogen proton doppler( MRS) scanning. The diagnostic value of dce-mri,DW1 and MRS scan in prostate cancer were investigated. Results A total of 46 patients with prostate cancer were found to have 52 cancer foci,among which 42 were low-signal T2 W1 nodules,3 were iso-signal nodules,3 were highsignal nodules,and 4 were low-signal mixed nodules. The lesions were located in the peripheral zone( 29) and the central zone( 23) respectively. Among them,there were 30 cases with cancer foci protruding capsule,14 cases of seminal vesicle invasion and 8 cases of bone metastasis. All volunteers had nodules located in the central zone,with relatively low T1 W1 signal,26 T2 W1 low-signal nodules,17 iso-signal nodules,and 8 low-signal nodules. The TIC by DCE-MRI scan in the two groups had statistical difference( P < 0. 05). ADC value in the prostate cancer group was significantly lower than that in the control group,and the ratio of( Cre + Cho)/Cit in the prostate cancer group was significantly higher than that in the control group,with statistically significant difference( P < 0. 05). Conclusion TIC by DCE-MRI scan for patients with prostate cancer in eastern Guangdong is mostly of type Ⅱ or Ⅲ,which are difficult to diagnose. In DW1 and MRS scans,the ADC values in prostate cancer patients decrease significantly,( Cre + Cho)/Cit rate increases significantly. Therefore,DCE-MRI,DW1 and MRS joint scanning are suggested in clinical diagnosis to reduce missed diagnosis and misdiagnosis.更多还原