【摘要】 背景:随着医疗水平的提高,临床对骨修复材料的需求逐渐增多,要求也越来越高。目的:综述近年来骨修复材料领域的相关研究进展,分析不同材料的优缺点,展望该领域的未来发展。方法:以"组织工程学、骨修复材料、骨缺损、天然骨材料、骨移植替代材料、中药;Tissue engineering、Bone repair material、Bone defect、Natural bone material、Bone graft replacement material、traditional Chinese medicine"等作为关键词,在CNKI、万方数据学库、Pub Med、Web of Science数据库进行检索,文献的语种限定为中文和英文,检索时间为1950至2019年。共检索到文献900余篇,最终纳入68篇进行综述。结果与结论:近年来随着组织工程学的蓬勃发展,骨组织修复材料的研究方兴未艾,除在天然骨的基础上对天然骨进行优化之外,也开发了各式各样的骨移植替代材料,如天然高分子材料、合成高分子材料、生物医用陶瓷材料、生物医用金属材料等,但这些材料性能不一,水平参差不齐,所以目前骨修复材料虽多,但理想的骨修复材料在临床的应用依然较少,因而骨缺损修复和重建仍是目前临床亟待解决的骨科难题之一。另外,将传统应用于骨修复的中药如自然铜与现代骨修复材料相结合应用,可有效规避现行各种骨修复材料的一些弊端,有效发挥治疗骨缺损疾病的作用,是骨修复领域一个值得深入研究的方向。更多还原

【Abstract】 BACKGROUND: With the improvement in medical level, the clinical demand for bone repair materials is gradually increasing, and the requirements are also getting more and more. OBJECTIVE: To review the related research progress in the field of bone repair materials in recent years, to analyze the advantages and disadvantages of different materials, and to guide future development in this research field. METHODS: A computer-based online search of CNKI, Wanfang, PubMed, Web of Science databases was performed to retrieve papers published during 1950-2019 with the search terms "tissue engineering, bone repair material, bone defect, natural bone material, bone graft replacement material, traditional Chinese medicine" in Chinese and English. A total of over 900 papers were retrieved, and 68 of them were included in the final analysis. RESULTS AND CONCLUSION: In recent year, with the flourish development of bone tissue engineering, the research of bone tissue repair materials is in the ascendant. In addition to optimizing natural bone, a variety of bone graft substitute materials have been developed, for example, natural macromolecule materials, synthetic macromolecule materials, biomedical ceramics materials, biomedical metal materials, etc., but these materials have different properties. Although there are many bone repair materials at present, the ideal bone repair materials are few. Therefore, bone tissue repair and bone remodeling is still one of the urgent orthopedic problems to be solved in the clinic. In addition, the traditional Chinese medicine for bone repair, such as pyritum combined with modern bone repair materials, can effectively avoid some of the drawbacks of the current bone repair materials, thereby effectively treating bone defect diseases. This deserves in-depth investigation in the field of bone repair.更多还原